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Glycogen synthase kinase 3 beta in Toll-like receptor signaling
- Glycogen synthase kinase 3 beta in Toll-like receptor signaling
- Ko, Ryeojin; Lee, Soo Young
- Ewha Authors
- SCOPUS Author ID
- Issue Date
- Journal Title
- BMB REPORTS
- 1976-6696; 1976-670X
- vol. 49, no. 6, pp. 305 - 310
- Glycogen synthase kinase 3 beta (GSK3 beta); Inflammatory cytokines; Toll-like receptor (TLR); Type I interferons (IFNs)
- KOREAN SOCIETY BIOCHEMISTRY & MOLECULAR BIOLOGY
- SCIE; SCOPUS; KCI
- Toll-like receptors (TLRs) play a critical role in the innate immune response against pathogens. Each TLR recognizes specific pathogen-associated molecular patterns, after which they activate the adaptor protein MyD88 or TRIF-assembled signaling complex to produce immune mediators, including inflammatory cytokines and type I IFNs. Although the activation of TLR is important for host defense, its uncontrolled activation can damage the host. During the past decade, numerous studies have demonstrated that GSK3 beta is a key regulator of inflammatory cytokine production in MyD88-mediated TLR signaling via TLR2 and TLR4. Recently, GSK3 beta has also been implicated in the TRIF-dependent signaling pathway via TLR3. In this review, we describe current advances on the regulatory role of GSK3 beta in immune responses associated with various TLRs. A better understanding of the role of GSK3 beta. in TLR signaling might lead to more effective anti-inflammatory interventions.
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- 자연과학대학 > 생명과학전공 > Journal papers
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