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Glycogen synthase kinase 3 beta in Toll-like receptor signaling

Title
Glycogen synthase kinase 3 beta in Toll-like receptor signaling
Authors
Ko, RyeojinLee, Soo Young
Ewha Authors
이수영
SCOPUS Author ID
이수영scopus
Issue Date
2016
Journal Title
BMB REPORTS
ISSN
1976-6696JCR Link1976-670XJCR Link
Citation
vol. 49, no. 6, pp. 305 - 310
Keywords
Glycogen synthase kinase 3 beta (GSK3 beta)Inflammatory cytokinesToll-like receptor (TLR)Type I interferons (IFNs)
Publisher
KOREAN SOCIETY BIOCHEMISTRY & MOLECULAR BIOLOGY
Indexed
SCIE; SCOPUS; KCI WOS scopus
Abstract
Toll-like receptors (TLRs) play a critical role in the innate immune response against pathogens. Each TLR recognizes specific pathogen-associated molecular patterns, after which they activate the adaptor protein MyD88 or TRIF-assembled signaling complex to produce immune mediators, including inflammatory cytokines and type I IFNs. Although the activation of TLR is important for host defense, its uncontrolled activation can damage the host. During the past decade, numerous studies have demonstrated that GSK3 beta is a key regulator of inflammatory cytokine production in MyD88-mediated TLR signaling via TLR2 and TLR4. Recently, GSK3 beta has also been implicated in the TRIF-dependent signaling pathway via TLR3. In this review, we describe current advances on the regulatory role of GSK3 beta in immune responses associated with various TLRs. A better understanding of the role of GSK3 beta. in TLR signaling might lead to more effective anti-inflammatory interventions.
DOI
10.5483/BMBRep.2016.49.6.059
Appears in Collections:
자연과학대학 > 생명과학전공 > Journal papers
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