Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 최혜영 | * |
dc.contributor.author | 최유원 | * |
dc.contributor.author | 박상희 | * |
dc.contributor.author | 변지연 | * |
dc.date.accessioned | 2016-11-15T02:11:28Z | - |
dc.date.available | 2016-11-15T02:11:28Z | - |
dc.date.issued | 2016 | * |
dc.identifier.issn | 1013-9087 | * |
dc.identifier.other | OAK-19541 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/232638 | - |
dc.description.abstract | Background: The role of the phosphatidylinositol-3 kinase signaling pathway in the development of acral melanoma has recently gained evidence. Phosphatase and tensin homologue (PTEN), one of the key molecules in the pathway, acts as a tumor suppressor through either an Akt-dependent or Akt-independent pathway. Akt accelerates degradation of p53. Objective: We assessed the expression of PTEN, phospho-Akt (p-Akt), and p53 by immunohistochemistry in benign acral nevi, acral dysplastic nevi, and acral melanomas in the radial growth phase and with a vertical growth component. Methods: Ten specimens in each group were included. Paraffin-embedded specimens were immunostained with antibodies for PTEN, p-Akt, and p53. We scored both the staining intensity and the proportion of positive cells. The final score was calculated by multiplying the intensity score by the proportion score. Results: All specimens of benign acral nevi except one showed some degree of PTEN-negative cells. The numbers of p-Akt and p53-positive cells were higher in acral dysplastic nevi and melanoma than in benign nevi. P-Akt scores were 1.7, 1.8, 2.6, and 4.4, and p53 scores were 2.0, 2.1, 3.8, and 4.1 in each group. PTEN and p-Akt scores in advanced acral melanoma were higher than in the other neoplasms. Conclusion: The expression of PTEN was decreased and the expression of p-Akt was increased in acral melanoma, especially in advanced cases. The PTEN-induced pathway appears to affect the late stage of melano-magenesis. Altered expression of p-Akt is thought to be due to secondary changes following the loss of PTEN. | * |
dc.language | English | * |
dc.publisher | KOREAN DERMATOLOGICAL ASSOC | * |
dc.subject | Acral | * |
dc.subject | Akt | * |
dc.subject | Melanocytic | * |
dc.subject | p53 | * |
dc.subject | PTEN | * |
dc.title | Expression of Phosphatase and Tensin Homologue, phospho-Akt, and p53 in Acral Benign and Malignant Melanocytic Neoplasms (Benign Nevi, Dysplastic Nevi, and Acral Melanomas) | * |
dc.type | Article | * |
dc.relation.issue | 5 | * |
dc.relation.volume | 28 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.index | KCI | * |
dc.relation.startpage | 548 | * |
dc.relation.lastpage | 554 | * |
dc.relation.journaltitle | ANNALS OF DERMATOLOGY | * |
dc.identifier.doi | 10.5021/ad.2016.28.5.548 | * |
dc.identifier.wosid | WOS:000385786200003 | * |
dc.identifier.scopusid | 2-s2.0-84991461521 | * |
dc.author.google | Lyu, So Min | * |
dc.author.google | Wu, Ju Yeon | * |
dc.author.google | Byun, Ji Yeon | * |
dc.author.google | Choi, Hae Young | * |
dc.author.google | Park, Sang Hee | * |
dc.author.google | Choi, You Won | * |
dc.contributor.scopusid | 최혜영(55724363200) | * |
dc.contributor.scopusid | 최유원(7404777738) | * |
dc.contributor.scopusid | 박상희(12041890800) | * |
dc.contributor.scopusid | 변지연(15724462400) | * |
dc.date.modifydate | 20240222131101 | * |