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Expression of Phosphatase and Tensin Homologue, phospho-Akt, and p53 in Acral Benign and Malignant Melanocytic Neoplasms (Benign Nevi, Dysplastic Nevi, and Acral Melanomas)

Title
Expression of Phosphatase and Tensin Homologue, phospho-Akt, and p53 in Acral Benign and Malignant Melanocytic Neoplasms (Benign Nevi, Dysplastic Nevi, and Acral Melanomas)
Authors
Lyu, So MinWu, Ju YeonByun, Ji YeonChoi, Hae YoungPark, Sang HeeChoi, You Won
Ewha Authors
최혜영최유원박상희변지연
SCOPUS Author ID
최혜영scopus; 최유원scopus; 박상희scopus; 변지연scopus
Issue Date
2016
Journal Title
ANNALS OF DERMATOLOGY
ISSN
1013-9087JCR Link
Citation
vol. 28, no. 5, pp. 548 - 554
Keywords
AcralAktMelanocyticp53PTEN
Publisher
KOREAN DERMATOLOGICAL ASSOC
Indexed
SCIE; SCOPUS; KCI WOS scopus
Abstract
Background: The role of the phosphatidylinositol-3 kinase signaling pathway in the development of acral melanoma has recently gained evidence. Phosphatase and tensin homologue (PTEN), one of the key molecules in the pathway, acts as a tumor suppressor through either an Akt-dependent or Akt-independent pathway. Akt accelerates degradation of p53. Objective: We assessed the expression of PTEN, phospho-Akt (p-Akt), and p53 by immunohistochemistry in benign acral nevi, acral dysplastic nevi, and acral melanomas in the radial growth phase and with a vertical growth component. Methods: Ten specimens in each group were included. Paraffin-embedded specimens were immunostained with antibodies for PTEN, p-Akt, and p53. We scored both the staining intensity and the proportion of positive cells. The final score was calculated by multiplying the intensity score by the proportion score. Results: All specimens of benign acral nevi except one showed some degree of PTEN-negative cells. The numbers of p-Akt and p53-positive cells were higher in acral dysplastic nevi and melanoma than in benign nevi. P-Akt scores were 1.7, 1.8, 2.6, and 4.4, and p53 scores were 2.0, 2.1, 3.8, and 4.1 in each group. PTEN and p-Akt scores in advanced acral melanoma were higher than in the other neoplasms. Conclusion: The expression of PTEN was decreased and the expression of p-Akt was increased in acral melanoma, especially in advanced cases. The PTEN-induced pathway appears to affect the late stage of melano-magenesis. Altered expression of p-Akt is thought to be due to secondary changes following the loss of PTEN.
DOI
10.5021/ad.2016.28.5.548
Appears in Collections:
의학전문대학원 > 의학과 > Journal papers
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