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The KMDS-NATION Study: Korean Movement Disorders Society Multicenter Assessment of Non-Motor Symptoms and Quality of Life in Parkinson's Disease NATION Study Group

Title
The KMDS-NATION Study: Korean Movement Disorders Society Multicenter Assessment of Non-Motor Symptoms and Quality of Life in Parkinson's Disease NATION Study Group
Authors
Kwon, Do-YoungKoh, Seong-BeomLee, Jae HyeokPark, Hee KyungKim, Han-JoonShin, Hae-WonYoun, JinyoungPark, Kun WooChoi, Sun-AhKim, Sang JinChoi, Seong-MinPark, Ji-YunJeon, Beom S.Kim, Ji YoungChung, Sun JuLee, Chong SikPark, Jeong-HoAhn, Tae-BeomKim, Won ChanKim, Hyun SookCheon, Sang MyungKim, Hee-TaeLee, Jee-YoungKim, Ji SunKim, Eun-JooKim, Jong-MinLee, Kwang SooKim, Joong-SeokKim, Min-JeongBaik, Jong SamPark, Ki-JongKim, Hee JinPark, Mee YoungKang, Ji HoonSong, Sook KunKim, Yong DukYun, Ji YoungLee, Ho-WonOh, Hyung GeunCho, JinwhanSong, In-UkSohn, Young H.Lee, Phil HyuKim, Jae Woo
Ewha Authors
윤지영
SCOPUS Author ID
윤지영scopusscopus
Issue Date
2016
Journal Title
JOURNAL OF CLINICAL NEUROLOGY
ISSN
1738-6586JCR Link2005-5013JCR Link
Citation
vol. 12, no. 4, pp. 393 - 402
Keywords
Parkinson's diseasenon-motor symptomsquality of life
Publisher
KOREAN NEUROLOGICAL ASSOC
Indexed
SCIE; SCOPUS; KCI WOS scopus
Abstract
Background and Purpose Nonmotor symptoms (NMS) in Parkinson's disease (PD) have multisystem origins with heterogeneous manifestations that develop throughout the course of PD. NMS are increasingly recognized as having a significant impact on the health-related quality of life (HrQoL). We aimed to determine the NMS presentation according to PD status, and the associations of NMS with other clinical variables and the HrQoL of Korean PD patients. Methods We surveyed patients in 37 movement-disorders clinics throughout Korea. In total, 323 PD patients were recruited for assessment of disease severity and duration, NMS, HrQoL, and other clinical variables including demographics, cognition, sleep scale, fatigability, and symptoms. Results In total, 98.1% of enrolled PD subjects suffered from various kinds of NMS. The prevalence of NMS and scores in each NMS domain were significantly higher in the PD group, and the NMS worsened as the disease progressed. Among clinical variables, disease duration and depressive mood showed significant correlations with all NMS domains (p<0.001). NMS status impacted HrQoL in PD (rS=0.329, p<0.01), and the association patterns differed with the disease stage. Conclusions The results of our survey suggest that NMS in PD are not simply isolated symptoms of degenerative disease, but rather exert significant influences throughout the disease course. A novel clinical approach focused on NMS to develop tailored management strategies is warranted to improve the HrQoL in PD patients.
DOI
10.3988/jcn.2016.12.4.393
Appears in Collections:
의료원 > 의료원 > Journal papers
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