Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 오세관 | * |
dc.date.accessioned | 2016-11-15T02:11:20Z | - |
dc.date.available | 2016-11-15T02:11:20Z | - |
dc.date.issued | 2016 | * |
dc.identifier.issn | 1226-8453 | * |
dc.identifier.issn | 2093-4947 | * |
dc.identifier.other | OAK-19662 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/232591 | - |
dc.description.abstract | Background: Red ginseng and ginsenosides have shown plethoric effects against various ailments. However, little is known regarding the effect of red ginseng on morphine-induced dependence and tolerance. We therefore investigated the effect of red ginseng extract (RGE) and biotransformed ginsenosides Rh2, Rg3, and compound K on morphine-induced dependence in mice and rats. Methods: While mice were pretreated with RGE and then morphine was injected intraperitoneally, rats were infused with ginsenosides and morphine intracranially for 7 days. Naloxone-induced morphine withdrawal syndrome was estimated and conditioned place preference test was performed for physical and psychological dependence, respectively. Western blotting was used to measure protein expressions. Results: Whereas RGE inhibited the number of naloxone-precipitated jumps and reduced conditioned place preference score, it restored the level of glutathione in mice. Likewise, ginsenosides Rh2, Rg3, and compound K attenuated morphine-dependent behavioral patterns such as teeth chattering, grooming, wet-dog shake, and escape behavior in rats. Moreover, activated N-methyl-D-aspartate acid receptor subunit 1 and extracellular signal-regulated kinase in the frontal cortex of rats, and cultured cortical neurons from mice were downregulated by ginsenosides Rh2, Rg3, and compound K despite their differential effects. Conclusion: RGE and biotransformed ginsenosides could be considered as potential therapeutic agents against morphine-induced dependence. Copyright (C) 2016, The Korean Society of Ginseng, Published by Elsevier. | * |
dc.language | English | * |
dc.publisher | KOREAN SOC GINSENG | * |
dc.subject | biotransformation | * |
dc.subject | ginsenosides | * |
dc.subject | morphine dependence | * |
dc.subject | red ginseng extract | * |
dc.title | Morphine dependence is attenuated by red ginseng extract and ginsenosides Rh2, Rg3, and compound K | * |
dc.type | Article | * |
dc.relation.issue | 4 | * |
dc.relation.volume | 40 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.index | KCI | * |
dc.relation.startpage | 445 | * |
dc.relation.lastpage | 452 | * |
dc.relation.journaltitle | JOURNAL OF GINSENG RESEARCH | * |
dc.identifier.doi | 10.1016/j.jgr.2016.08.006 | * |
dc.identifier.wosid | WOS:000385910600018 | * |
dc.author.google | Yayeh, Taddesse | * |
dc.author.google | Yun, Kyunghwa | * |
dc.author.google | Jang, Soyong | * |
dc.author.google | Oh, Seikwan | * |
dc.contributor.scopusid | 오세관(7404103757) | * |
dc.date.modifydate | 20240118133340 | * |