View : 12 Download: 0

Morphine dependence is attenuated by red ginseng extract and ginsenosides Rh2, Rg3, and compound K

Title
Morphine dependence is attenuated by red ginseng extract and ginsenosides Rh2, Rg3, and compound K
Authors
Yayeh, TaddesseYun, KyunghwaJang, SoyongOh, Seikwan
Ewha Authors
오세관
SCOPUS Author ID
오세관scopus
Issue Date
2016
Journal Title
JOURNAL OF GINSENG RESEARCH
ISSN
1226-8453JCR Link2093-4947JCR Link
Citation
vol. 40, no. 4, pp. 445 - 452
Keywords
biotransformationginsenosidesmorphine dependencered ginseng extract
Publisher
KOREAN SOC GINSENG
Indexed
SCIE; SCOPUS; KCI WOS
Abstract
Background: Red ginseng and ginsenosides have shown plethoric effects against various ailments. However, little is known regarding the effect of red ginseng on morphine-induced dependence and tolerance. We therefore investigated the effect of red ginseng extract (RGE) and biotransformed ginsenosides Rh2, Rg3, and compound K on morphine-induced dependence in mice and rats. Methods: While mice were pretreated with RGE and then morphine was injected intraperitoneally, rats were infused with ginsenosides and morphine intracranially for 7 days. Naloxone-induced morphine withdrawal syndrome was estimated and conditioned place preference test was performed for physical and psychological dependence, respectively. Western blotting was used to measure protein expressions. Results: Whereas RGE inhibited the number of naloxone-precipitated jumps and reduced conditioned place preference score, it restored the level of glutathione in mice. Likewise, ginsenosides Rh2, Rg3, and compound K attenuated morphine-dependent behavioral patterns such as teeth chattering, grooming, wet-dog shake, and escape behavior in rats. Moreover, activated N-methyl-D-aspartate acid receptor subunit 1 and extracellular signal-regulated kinase in the frontal cortex of rats, and cultured cortical neurons from mice were downregulated by ginsenosides Rh2, Rg3, and compound K despite their differential effects. Conclusion: RGE and biotransformed ginsenosides could be considered as potential therapeutic agents against morphine-induced dependence. Copyright (C) 2016, The Korean Society of Ginseng, Published by Elsevier.
DOI
10.1016/j.jgr.2016.08.006
Appears in Collections:
의학전문대학원 > 의학과 > Journal papers
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE