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Synthesis, structural characterization and biological evaluation of novel stilbene derivatives as potential antimalarial agents

Title
Synthesis, structural characterization and biological evaluation of novel stilbene derivatives as potential antimalarial agents
Authors
Jung M.Park W.-H.Jung J.-C.Lim E.Lee Y.Oh S.Moon H.-I.
Ewha Authors
오세관
SCOPUS Author ID
오세관scopus
Issue Date
2009
Journal Title
Chemical Biology and Drug Design
ISSN
1747-0277JCR Link
Citation
vol. 73, no. 3, pp. 346 - 354
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
A series of benzamide-containing stilbene derivatives was synthesized through the incorporation of short basic side-chains in the B-ring hydroxy position of resveratrol. Their antiplasmodial activity was evaluated in vitro against the chloroquine resistant Plasmodium falciparum D10 strain, showing IC50 values between 1.5 and 80 μm, while their cytotoxicity was assessed using an human myeloid leukemia (U-937) cell line. With a selectivity ratio of >51.02, the most selective of these derivatives, 29, also had the most lowest cytotoxic activity of the series. © 2009 Blackwell Munksgaard.
DOI
10.1111/j.1747-0285.2009.00775.x
Appears in Collections:
의과대학 > 의학과 > Journal papers
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