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Community level exposure to chemicals and oxidative stress in adult population

Title
Community level exposure to chemicals and oxidative stress in adult population
Authors
Hong Y.-C.Park E.-Y.Park M.-S.Ko J.A.Oh S.-Y.Kim H.Lee K.-H.Leem J.-H.Ha E.-H.
Ewha Authors
하은희
SCOPUS Author ID
하은희scopus
Issue Date
2009
Journal Title
Toxicology Letters
ISSN
0378-4274JCR Link
Citation
vol. 184, no. 2, pp. 139 - 144
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Little information is available on the role of environmental chemical exposure in oxidative stress. This study was designed to investigate whether exposure to environmental chemicals, such as polycyclic aromatic hydrocarbons, volatile organic compounds, bisphenol A or phthalates, induces oxidative stress in urban adult populations. A total of 960 adults dwelling in urban areas were evaluated between April and December 2005. To assess environmental chemical exposure, we measured urinary levels of 1-hydroxypyrene, 2-naphthol, hippuric acid, methyl hippuric acid, mono-(2-ethyl-5-hydroxyhexyl) phthalate, mono-(2-ethyl-5-oxohexyl) phthalate, and mono-butyl phthalate and bisphenol A. Urinary malondialdehyde and 8-hydroxydeoxyguanosine were also measured to evaluate oxidative stress. Significant dose-responsive relationship was found between urinary concentrations of the chemical exposure biomarkers and oxidative stress levels in simple regression analyses (P < 0.05). Regression coefficients of these exposure biomarkers except bisphenol A remained significantly in the multiple regression models after controlling for age, sex, weight, smoking, and exercise for at least one of the two oxidative stress biomarkers (P < 0.05). The oxidative stress biomarkers significantly affected the indicators of insulin resistance, particularly glucose level. This study indicates that environmental chemical exposure is associated with oxidative stress in urban adult populations and suggests that exposure to certain environmental chemicals might contribute to insulin resistance. © 2008 Elsevier Ireland Ltd. All rights reserved.
DOI
10.1016/j.toxlet.2008.11.001
Appears in Collections:
의학전문대학원 > 의학과 > Journal papers
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