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Interstitial tonicity controls TonEBP expression in the renal medulla

Title
Interstitial tonicity controls TonEBP expression in the renal medulla
Authors
Sheen M.R.Kim J.-A.Lim S.W.Jung J.-Y.Han K.-H.Jeon U.S.Park S.-H.Kim J.Kwon H.M.
Ewha Authors
한기환
SCOPUS Author ID
한기환scopus
Issue Date
2009
Journal Title
Kidney International
ISSN
0085-2538JCR Link
Citation
vol. 75, no. 5, pp. 518 - 525
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Cells in the hyperosmotic kidney medulla, express a transcriptional activator termed tonicity responsive enhancer binding protein (TonEBP). Genes targeted by TonEBP protect kidney cells from the deleterious effects of hyperosmolality by inducing the expression of organic osmolytes and molecular chaperones, and other genes that mediate urine concentration such as aquaporin-2 and urea transporters. We tested here the effect of hypertonicity and hyperosmotic salt in the renal medullary interstitium on the expression TonEBP. When massive water diuresis was induced in rats the medullary sodium concentrations did not change, neither did TonEBP expression. In these animals the medullary tonicity was unchanged despite the production of dilute urine. On the other hand, treatment with the loop diurectic furosemide resulted in a dose-dependent decrease in the medullary sodium concentration causing a reduction in interstitial tonicity. Here, TonEBP expression was blunted in the outer and inner medulla which was due, in part, to decreased mRNA abundance. As expected, the expression of TonEBP target genes in the renal medulla also decreased in response to furosemide. Hence TonEBP expression in the renal medulla is stimulated by interstitial hypertonicity. © 2009 International Society of Nephrology.
DOI
10.1038/ki.2008.601
Appears in Collections:
의학전문대학원 > 의학과 > Journal papers
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