Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김태헌 | * |
dc.date.accessioned | 2016-10-20T02:10:39Z | - |
dc.date.available | 2016-10-20T02:10:39Z | - |
dc.date.issued | 2009 | * |
dc.identifier.issn | 0006-291X | * |
dc.identifier.other | OAK-5404 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/232553 | - |
dc.description.abstract | One of the pathways by which alcohol induces hepatocyte apoptosis is via oxidative stress. We screened several chemically-synthesized small molecules and found LAS-0811, which inhibits oxidative stress. In this study, we elucidated its role in inhibiting alcohol-induced apoptosis in hepatocyte-like VL-17A cells. VL-17A cells were pre-incubated with LAS-0811, followed by ethanol incubation. Ethanol-induced reactive oxygen species and apoptosis were significantly inhibited in LAS-0811 pre-treated cells. VL-17A cells were transfected with a reporter (ARE/TK-GFP) plasmid containing green fluorescent protein (GFP) as a reporter gene and the anti-oxidant response element as the promoter. LAS-0811 pre-treatment significantly induced the GFP expression compared to the cells treated with ethanol alone. LAS-0811 induced the activation of nrf2 and enhanced the expression and activity of glutathione peroxidase, one of the downstream targets of nrf2. The results indicate that LAS-0811 protects VL-17A cells against ethanol-induced oxidative stress and apoptosis at least in part via nrf2 activation. © 2008 Elsevier Inc. All rights reserved. | * |
dc.language | English | * |
dc.title | A novel small molecule, LAS-0811, inhibits alcohol-induced apoptosis in VL-17A cells | * |
dc.type | Article | * |
dc.relation.issue | 4 | * |
dc.relation.volume | 379 | * |
dc.relation.index | SCI | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 876 | * |
dc.relation.lastpage | 881 | * |
dc.relation.journaltitle | Biochemical and Biophysical Research Communications | * |
dc.identifier.doi | 10.1016/j.bbrc.2008.12.133 | * |
dc.identifier.wosid | WOS:000263336700015 | * |
dc.identifier.scopusid | 2-s2.0-58949089381 | * |
dc.author.google | Kim T.-H. | * |
dc.author.google | Venugopal S.K. | * |
dc.author.google | Zhu M. | * |
dc.author.google | Wang S.-S. | * |
dc.author.google | Lau D. | * |
dc.author.google | Lam K.S. | * |
dc.author.google | Clemens D.L. | * |
dc.author.google | Zern M.A. | * |
dc.contributor.scopusid | 김태헌(57125156300;57219781484) | * |
dc.date.modifydate | 20240422114851 | * |