Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김경효 | * |
dc.date.accessioned | 2016-10-20T02:10:37Z | - |
dc.date.available | 2016-10-20T02:10:37Z | - |
dc.date.issued | 2009 | * |
dc.identifier.issn | 1556-6811 | * |
dc.identifier.other | OAK-5440 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/232530 | - |
dc.description.abstract | The currently available 7-valent pneumococcal conjugate vaccine (PCV7) elicits good immune response to and is effective against vaccine serotypes. However, its effectiveness against vaccine-related serotypes is variable. Serum samples were obtained 1 month after the last vaccination from 31 infants immunized with PCV7 at 2, 4, and 6 months of age. The sera were used to determine immunoglobulin G antibody levels to eight serotypes (seven vaccine serotypes and serotype 19A) with enzyme-linked immunosorbent assay (ELISA) and opsonic capacity against 11 serotypes (seven vaccine serotypes, serotypes 19A and 6A, and nonvaccine serotypes 5 and 7F) using a multiplexed opsonization assay. ELISA results showed antibody concentrations varied between 1.84 and 10.49 μg/ml, and all subjects had antibody concentrations of ≥0.35 μg/ml for all serotypes, including serotype 19A. In contrast, the opsonic index was detectable (i.e., opsonic index ≥ 8) in all children for the seven vaccine serotypes, 81% for serotype 6A, and merely 19% for serotype 19A. PCV7 shows good immunogenicity for vaccine serotypes in infants after a primary series. PCV7 does not elicit opsonic antibodies to serotype 19A. ELISA may thus be an inadequate surrogate assay for evaluating the response for crossreactive serotypes in infants. Copyright © 2009, American Society for Microbiology. All Rights Reserved. | * |
dc.language | English | * |
dc.title | Immune response in infants to the heptavalent pneumococcal conjugate vaccine against vaccine-related serotypes 6A and 19A | * |
dc.type | Article | * |
dc.relation.issue | 3 | * |
dc.relation.volume | 16 | * |
dc.relation.index | SCI | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 376 | * |
dc.relation.lastpage | 381 | * |
dc.relation.journaltitle | Clinical and Vaccine Immunology | * |
dc.identifier.doi | 10.1128/CVI.00344-08 | * |
dc.identifier.wosid | WOS:000263854200013 | * |
dc.identifier.scopusid | 2-s2.0-61949386874 | * |
dc.author.google | Lee H. | * |
dc.author.google | Nahm M.H. | * |
dc.author.google | Burton R. | * |
dc.author.google | Kim K.-H. | * |
dc.contributor.scopusid | 김경효(35448653000) | * |
dc.date.modifydate | 20240301081003 | * |