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The effects of terpenes on the permeation of lidocaine and ofloxacin from moisture-activated patches

Title
The effects of terpenes on the permeation of lidocaine and ofloxacin from moisture-activated patches
Authors
Song Y.H.Gwak H.S.Chun I.K.
Ewha Authors
곽혜선
SCOPUS Author ID
곽혜선scopus
Issue Date
2009
Journal Title
Drug Delivery
ISSN
1071-7544JCR Link
Citation
vol. 16, no. 2, pp. 75 - 81
Indexed
SCIE; SCOPUS WOS scopus
Abstract
The effects of terpenes on the release and permeation of ofloxacin and lidocaine from moisture-activated composite patches were investigated. Ofloxacin without enhancers showed very low permeation rate (0.58 μg/cm2/hr), and the addition of cineole enhanced the permeation flux 14.1-times; /-menthol and d-limonene increased it 4.7- and 3.5-times, respectively. The highest permeation flux (77.7 ± 25.3 μg/cm2/hr) of lidocaine from the composite patches was also achieved when cineole at the concentration of 0.33% in the gel base was added. /-Menthol also revealed enhancing effect on the permeation of lidocaine; however, d-limonene failed to increase the permeation rate of lidocaine. In conclusion, for effective moisture- activated patches containing lidocaine and ofloxacin, cineole could be used as an effective and safe enhancer. © 2009 Informa UK Ltd.
DOI
10.1080/10717540802586667
Appears in Collections:
약학대학 > 약학과 > Journal papers
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