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Analysis of hepatic gene expression during fatty liver change due to chronic ethanol administration in mice

Title
Analysis of hepatic gene expression during fatty liver change due to chronic ethanol administration in mice
Authors
Yin H.-Q.Je Y.-T.Kim M.Kim J.-H.Kong G.Kang K.-S.Kim H.-L.Yoon B.-I.Lee M.-O.Lee B.-H.
Ewha Authors
김형래
SCOPUS Author ID
김형래scopus
Issue Date
2009
Journal Title
Toxicology and Applied Pharmacology
ISSN
0041-008XJCR Link
Citation
vol. 235, no. 3, pp. 312 - 320
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Chronic consumption of ethanol can cause cumulative liver damage that can ultimately lead to cirrhosis. To explore the mechanisms of alcoholic steatosis, we investigated the global intrahepatic gene expression profiles of livers from mice administered alcohol. Ethanol was administered by feeding the standard Lieber-DeCarli diet, of which 36% (high dose) and 3.6% (low dose) of the total calories were supplied from ethanol for 1, 2, or 4 weeks. Histopathological evaluation of the liver samples revealed fatty changes and punctate necrosis in the high-dose group and ballooning degeneration in the low-dose group. In total, 292 genes were identified as ethanol responsive, and several of these differed significantly in expression compared to those of control mice (two-way ANOVA; p < 0.05). Specifically, the expression levels of genes involved in hepatic lipid transport and metabolism were examined. An overall net increase in gene expression was observed for genes involved in (i) glucose transport and glycolysis, (ii) fatty acid influx and de novo synthesis, (iii) fatty acid esterification to triglycerides, and (iv) cholesterol transport, de novo cholesterol synthesis, and bile acid synthesis. Collectively, these data provide useful information concerning the global gene expression changes that occur due to alcohol intake and provide important insights into the comprehensive mechanisms of chronic alcoholic steatosis. © 2009 Elsevier Inc. All rights reserved.
DOI
10.1016/j.taap.2008.12.018
Appears in Collections:
의과대학 > 의학과 > Journal papers
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