Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 이원재 | - |
dc.contributor.author | 강동민 | - |
dc.date.accessioned | 2016-10-20T02:10:35Z | - |
dc.date.available | 2016-10-20T02:10:35Z | - |
dc.date.issued | 2009 | - |
dc.identifier.issn | 1534-5807 | - |
dc.identifier.other | OAK-5483 | - |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/232506 | - |
dc.description.abstract | All metazoan guts are in constant contact with diverse food-borne microorganisms. The signaling mechanisms by which the host regulates gut-microbe interactions, however, are not yet clear. Here, we show that phospholipase C-β (PLCβ) signaling modulates dual oxidase (DUOX) activity to produce microbicidal reactive oxygen species (ROS) essential for normal host survival. Gut-microbe contact rapidly activates PLCβ through Gαq, which in turn mobilizes intracellular Ca2+ through inositol 1,4,5-trisphosphate generation for DUOX-dependent ROS production. PLCβ mutant flies had a short life span due to the uncontrolled propagation of an essential nutritional microbe, Saccharomyces cerevisiae, in the gut. Gut-specific reintroduction of the PLCβ restored efficient DUOX-dependent microbe-eliminating capacity and normal host survival. These results demonstrate that the Gαq-PLCβ-Ca2+-DUOX-ROS signaling pathway acts as a bona fide first line of defense that enables gut epithelia to dynamically control yeast during the Drosophila life cycle. © 2009 Elsevier Inc. All rights reserved. | - |
dc.language | English | - |
dc.title | Regulation of DUOX by the Gαq-Phospholipase Cβ-Ca2+ Pathway in Drosophila Gut Immunity | - |
dc.type | Article | - |
dc.relation.issue | 3 | - |
dc.relation.volume | 16 | - |
dc.relation.index | SCI | - |
dc.relation.index | SCIE | - |
dc.relation.index | SCOPUS | - |
dc.relation.startpage | 386 | - |
dc.relation.lastpage | 397 | - |
dc.relation.journaltitle | Developmental Cell | - |
dc.identifier.doi | 10.1016/j.devcel.2008.12.015 | - |
dc.identifier.wosid | WOS:000264368400009 | - |
dc.identifier.scopusid | 2-s2.0-61749104447 | - |
dc.author.google | Ha E.-M. | - |
dc.author.google | Lee K.-A. | - |
dc.author.google | Park S.H. | - |
dc.author.google | Kim S.-H. | - |
dc.author.google | Nam H.-J. | - |
dc.author.google | Lee H.-Y. | - |
dc.author.google | Kang D. | - |
dc.author.google | Lee W.-J. | - |
dc.contributor.scopusid | 이원재(57171092600) | - |
dc.contributor.scopusid | 강동민(13103841000) | - |
dc.date.modifydate | 20230210131016 | - |