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Berberine improves lipid dysregulation in obesity by controlling central and peripheral AMPK activity

Title
Berberine improves lipid dysregulation in obesity by controlling central and peripheral AMPK activity
Authors
Kim W.S.Lee Y.S.Cha S.H.Jeong H.W.Choe S.S.Lee M.-R.Oh G.T.Park H.-S.Lee K.-U.Lane M.D.Kim J.B.
Ewha Authors
오구택
SCOPUS Author ID
오구택scopus
Issue Date
2009
Journal Title
American Journal of Physiology - Endocrinology and Metabolism
ISSN
0193-1849JCR Link
Citation
vol. 296, no. 4, pp. E812 - E819
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
AMP-activated protein kinase (AMPK) plays an important role in regulating whole body energy homeostasis. Recently, it has been demonstrated that berberine (BBR) exerts antiobesity and antidiabetic effects in obese and diabetic rodent models through the activation of AMPK in peripheral tissues. Here we show that BBR improves lipid dysregulation and fatty liver in obese mice through central and peripheral actions. In obese db/db and ob/ob mice, BBR treatment reduced liver weight, hepatic and plasma triglyceride, and cholesterol contents. In the liver and muscle of db/db mice, BBR promoted AMPK activity and fatty acid oxidation and changed expression of genes involved in lipid metabolism. Additionally, intracerebroventricular administration of BBR decreased the level of malonyl-CoA and stimulated the expression of fatty acid oxidation genes in skeletal muscle. Together, these data suggest that BBR would improve fatty liver in obese subjects, which is probably mediated not only by peripheral AMPK activation but also by neural signaling from the central nervous system. Copyright © 2009 the American Physiological Society.
DOI
10.1152/ajpendo.90710.2008
Appears in Collections:
자연과학대학 > 생명과학전공 > Journal papers
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