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Novel small molecule activators of β-catenin-mediated signaling pathway: structure-activity relationships of indirubins

Title
Novel small molecule activators of β-catenin-mediated signaling pathway: structure-activity relationships of indirubins
Authors
Park E.-J.Choi S.J.Kim Y.-C.Lee S.H.Park S.W.Lee S.K.
Ewha Authors
이상국
Issue Date
2009
Journal Title
Bioorganic and Medicinal Chemistry Letters
ISSN
0960-894XJCR Link
Citation
vol. 19, no. 8, pp. 2282 - 2284
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Based on the β-catenin-drived Wnt activator of bromoindirubin-3′-oxime (BIO), indirubin analogs were evaluated for β-catenin-mediated gene expression. A novel indirubin analog, indirubin-5-nitro-3′-oxime (INO), was considered a potential activator, and structure-activity studies were conducted with indirubins. These data suggest that INO might be a novel Wnt activator and has a potential of signaling regulator in β-catenin-mediated signaling pathways. © 2009 Elsevier Ltd. All rights reserved.
DOI
10.1016/j.bmcl.2009.02.083
Appears in Collections:
약학대학 > 약학과 > Journal papers
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