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Effect of naturally occurring hydroxychavicol acetate on the cytokine production in T helper cells

Title
Effect of naturally occurring hydroxychavicol acetate on the cytokine production in T helper cells
Authors
Min H.J.Nam J.-W.Yu E.S.Hong J.-H.Seo E.-K.Hwang E.S.
Ewha Authors
서은경황은숙
SCOPUS Author ID
서은경scopus; 황은숙scopus
Issue Date
2009
Journal Title
International Immunopharmacology
ISSN
1567-5769JCR Link
Citation
vol. 9, no. 4, pp. 448 - 454
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Naturally occurring phenolic compounds, such as chavicol analogues, have been shown to have potent antioxidant and anti-inflammatory activities. We have previously isolated two chavicol acetate analogues, acetoxychavicol acetate (ACA) and hydroxychavicol acetate (HCA) from the rhizomes of Alpinia galanga. Although the function of ACA has been studied in many systems, the function of HCA has yet to be systemically examined. In this study, we have comparably examined the functions of ACA and HCA on the cytokine production in Th cells. ACA exhibited potent antioxidant activity and increased cell apoptosis; therefore, cytokine production by Th cells was diminished. Although HCA had neither antioxidant activity nor pro-apoptotic function, it was shown to increase IL-2 production and attenuate IFNγ expression in Th cells. In addition, we demonstrated that HCA suppressed T-bet expression, which is responsible for IL-2 suppression and IFNγ induction in Th cells and inhibited T-bet-mediated Th1 cell differentiation. Therefore, we suggest that HCA may be beneficial as therapeutics for treating inflammatory immune disorders caused by extravagant activation of Th1-mediated immune responses. © 2009 Elsevier B.V. All rights reserved.
DOI
10.1016/j.intimp.2009.01.008
Appears in Collections:
약학대학 > 약학과 > Journal papers
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