Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 이종란 | - |
dc.date.accessioned | 2016-10-20T02:10:29Z | - |
dc.date.available | 2016-10-20T02:10:29Z | - |
dc.date.issued | 2009 | - |
dc.identifier.issn | 0944-7113 | - |
dc.identifier.other | OAK-5556 | - |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/232462 | - |
dc.description.abstract | In this study, the effects of the extract and four tanshinone compounds from the dried root of Salvia miltiorrhiza Bunge (Labiatae) on the tyrosine phosphorylation of the insulin receptor (IR) β-subunit and the downstream signaling were examined in Chinese-hamster ovary cells expressing human insulin receptors (CHO/IR cells) as well as in 3T3-L1 adipocytes. In addition the translocation of the glucose transporter 4 was investigated in 3T3-L1 adipocytes. Total extract of Danshen (1-10 μg/ml) and the four tanshinones (10 μM) did not show any activity, but the total extract and the tanshinone I, IIA and 15, 16-dihydrotanshinone I except cryptotanshinone enhanced the activity of insulin (1 nM) on the tyrosine phosphorylation of the IR as well as the activation of the downstream kinases Akt, ERK1/2, and GSK3β. In the adipocytes the same IR-downstream signaling and the translocation of glucose transporter 4 were demonstrated by the three tanshinones in the presence of insulin. These insulin-sensitizing activities of tanshinones may be useful for developing a new class of specific IR activators as anti-diabetic agents. © 2008 Elsevier GmbH. All rights reserved. | - |
dc.language | English | - |
dc.title | Insulin-sensitizing activities of tanshinones, diterpene compounds of the root of Salvia miltiorrhiza Bunge | - |
dc.type | Article | - |
dc.relation.issue | 4 | - |
dc.relation.volume | 16 | - |
dc.relation.index | SCIE | - |
dc.relation.index | SCOPUS | - |
dc.relation.startpage | 327 | - |
dc.relation.lastpage | 335 | - |
dc.relation.journaltitle | Phytomedicine | - |
dc.identifier.doi | 10.1016/j.phymed.2008.12.017 | - |
dc.identifier.wosid | WOS:000265339200009 | - |
dc.identifier.scopusid | 2-s2.0-62549164227 | - |
dc.author.google | Jung S.H. | - |
dc.author.google | Seol H.J. | - |
dc.author.google | Jeon S.J. | - |
dc.author.google | Son K.H. | - |
dc.author.google | Lee J.R. | - |
dc.contributor.scopusid | 이종란(37960967100) | - |
dc.date.modifydate | 20230411105011 | - |