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Insulin-sensitizing activities of tanshinones, diterpene compounds of the root of Salvia miltiorrhiza Bunge

Title
Insulin-sensitizing activities of tanshinones, diterpene compounds of the root of Salvia miltiorrhiza Bunge
Authors
Jung S.H.Seol H.J.Jeon S.J.Son K.H.Lee J.R.
Ewha Authors
이종란
SCOPUS Author ID
이종란scopus
Issue Date
2009
Journal Title
Phytomedicine
ISSN
0944-7113JCR Link
Citation
vol. 16, no. 4, pp. 327 - 335
Indexed
SCIE; SCOPUS WOS scopus
Abstract
In this study, the effects of the extract and four tanshinone compounds from the dried root of Salvia miltiorrhiza Bunge (Labiatae) on the tyrosine phosphorylation of the insulin receptor (IR) β-subunit and the downstream signaling were examined in Chinese-hamster ovary cells expressing human insulin receptors (CHO/IR cells) as well as in 3T3-L1 adipocytes. In addition the translocation of the glucose transporter 4 was investigated in 3T3-L1 adipocytes. Total extract of Danshen (1-10 μg/ml) and the four tanshinones (10 μM) did not show any activity, but the total extract and the tanshinone I, IIA and 15, 16-dihydrotanshinone I except cryptotanshinone enhanced the activity of insulin (1 nM) on the tyrosine phosphorylation of the IR as well as the activation of the downstream kinases Akt, ERK1/2, and GSK3β. In the adipocytes the same IR-downstream signaling and the translocation of glucose transporter 4 were demonstrated by the three tanshinones in the presence of insulin. These insulin-sensitizing activities of tanshinones may be useful for developing a new class of specific IR activators as anti-diabetic agents. © 2008 Elsevier GmbH. All rights reserved.
DOI
10.1016/j.phymed.2008.12.017
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자연과학대학 > 생명과학전공 > Journal papers
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