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Multi-institutional comparison of intensity modulated radiation therapy (IMRT) planning strategies and planning results for nasopharyngeal cancer

Title
Multi-institutional comparison of intensity modulated radiation therapy (IMRT) planning strategies and planning results for nasopharyngeal cancer
Authors
Park S.H.Park H.C.Park S.W.Oh D.H.Choi Y.Kim J.K.Ahn Y.C.Park W.Suh H.S.Lee R.Bae H.
Ewha Authors
서현숙이레나
SCOPUS Author ID
이레나scopus
Issue Date
2009
Journal Title
Journal of Korean Medical Science
ISSN
1011-8934JCR Link
Citation
vol. 24, no. 2, pp. 248 - 255
Indexed
SCI; SCIE; SCOPUS; KCI WOS scopus
Abstract
The intensity-modulated radiation therapy (IMRT) planning strategies for nasopharyngeal cancer among Korean radiation oncology facilities were investigated. Five institutions with IMRT planning capacity using the same planning system were invited to participate in this study. The institutions were requested to produce the best plan possible for 2 cases that would deliver 70 Gy to the planning target volume of gross tumor (PTV1), 59.4 Gy to the PTV2, and 51.5 Gy to the PTV3 in which elective irradiation was required. The advised fractionation number was 33. The planning parameters, resultant dose distributions, and biological indices were compared. We found 2-3-fold variations in the volume of treatment targets. Similar degree of variation was found in the delineation of normal tissue. The physician-related factors in IMRT planning had more influence on the plan quality. The inhomogeneity index of PTV dose ranged from 4 to 49% in Case 1, and from 5 to 46% in Case 2. Variation in tumor control probabilities for the primary lesion and involved LNs was less marked. Normal tissue complication probabilities for parotid glands and skin showed marked variation. Results from this study suggest that greater efforts in providing training and continuing education in terms of IMRT planning parameters usually set by physician are necessary for the successful implementation of IMRT. Copyright © The Korean Academy of Medical Sciences.
DOI
10.3346/jkms.2009.24.2.248
Appears in Collections:
의학전문대학원 > 의학과 > Journal papers
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