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The association between pulse wave velocity and metabolic syndrome and adiponectin in patients with impaired fasting glucose: Cardiovascular risks and adiponectin in IFG

Title
The association between pulse wave velocity and metabolic syndrome and adiponectin in patients with impaired fasting glucose: Cardiovascular risks and adiponectin in IFG
Authors
Nam J.S.Park J.S.Cho M.H.Jee S.H.Lee H.S.Ahn C.W.Lowe Jr. W.L.Kim K.R.
Ewha Authors
이홍수
SCOPUS Author ID
이홍수scopus
Issue Date
2009
Journal Title
Diabetes Research and Clinical Practice
ISSN
0168-8227JCR Link
Citation
vol. 84, no. 2, pp. 145 - 151
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
We aimed to assess how metabolic profiles, surrogate markers of insulin resistance, and subclinical atherosclerosis are interrelated in subjects with impaired fasting glucose (IFG) and investigate whether the diagnosis of metabolic syndrome (MetS) further increases the risk of cardiovascular disease among subjects already at risk. We analyzed 1739 Korean subjects with IFG. The parameters of MetS, plasma adiponectin level, and pulse wave velocity (PWV) were assessed. Subjects with MetS had unfavorable metabolic parameters, lower adiponectin level, and higher peripheral PWV compared to those without MetS. Adiponectin correlated with fasting glucose, waist circumference, triglyceride, HDL-cholesterol, BMI, HOMA-IR, and the number of MetS components. In addition to blood pressure, peripheral PWV was associated with triglyceride, waist circumference, and the number of MetS components while aortic PWV correlated positively with fasting plasma glucose. Multiple linear regression analysis revealed that adiponectin correlated with HDL-cholesterol, HOMA-IR, fasting glucose, waist circumference, and triglyceride, peripheral PWV with blood pressure, body mass index, waist circumference, and the number of MetS components, and aortic PWV with fasting plasma glucose. In subjects with IFG, concurrent MetS increases PWV and has an unfavorable effect on cardiovascular risks, and these risks were further increased by additional MetS components. © 2009 Elsevier Ireland Ltd. All rights reserved.
DOI
10.1016/j.diabres.2009.02.002
Appears in Collections:
의과대학 > 의학과 > Journal papers
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