Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 이동현 | - |
dc.date.accessioned | 2016-10-15T01:10:22Z | - |
dc.date.available | 2016-10-15T01:10:22Z | - |
dc.date.issued | 2009 | - |
dc.identifier.issn | 0165-4608 | - |
dc.identifier.other | OAK-5597 | - |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/232413 | - |
dc.description.abstract | The Toll-like receptor 4 (TLR4) has a wide spectrum of bacteria recognition receptors that may be involved in the signaling of the immune responses in the prostate. A few association studies have assessed the relationship between the risk of prostate cancer (PC) and the polymorphism in the TLR4 gene in European-ancestry populations. To evaluate the association of TLR4 polymorphisms and the risk for PC in Korean men, we genotyped five single-nucleotide polymorphisms (SNPs) of the TRL4 gene (rs11536858, rs1927914, 1927911, rs11536891, and rs11536897) by PCR-restriction fragment length polymorphism from unrelated 157 PC patients and 143 age-matched controls. The rs1927911 SNP increased the risk of PC (adjusted odds ratio ORadj = 2.73, 95% CI = 1.54-4.87 for the TC genotype; ORadj = 6.68, 95% CI = 3.27-13.66 for the CC genotype). The GG genotype of the rs11536858 SNP also carried increased risk (ORadj = 2.296, 95% CI = 1.07-4.93). There was no statistically significant correlation between any of the SNPs of TRL4 and such PC prognostic factors as Gleason grade, initial prostate-specific antigen level, or tumor stage. In conclusion, inherited differences in the TLR4 gene influence the risk of PC in Korean men. © 2009 Elsevier Inc. All rights reserved. | - |
dc.language | English | - |
dc.title | The association between Toll-like receptor 4 (TLR4) polymorphisms and the risk of prostate cancer in Korean men | - |
dc.type | Article | - |
dc.relation.issue | 2 | - |
dc.relation.volume | 190 | - |
dc.relation.index | SCOPUS | - |
dc.relation.startpage | 88 | - |
dc.relation.lastpage | 92 | - |
dc.relation.journaltitle | Cancer Genetics and Cytogenetics | - |
dc.identifier.doi | 10.1016/j.cancergencyto.2008.12.011 | - |
dc.identifier.wosid | WOS:000265775200006 | - |
dc.identifier.scopusid | 2-s2.0-64549116737 | - |
dc.author.google | Song J. | - |
dc.author.google | Kim D.Y. | - |
dc.author.google | Kim C.S. | - |
dc.author.google | Kim H.J. | - |
dc.author.google | Lee D.H. | - |
dc.author.google | Lee H. | - |
dc.author.google | Ko W. | - |
dc.author.google | Lee G. | - |
dc.contributor.scopusid | 이동현(24341048900;57202299352) | - |
dc.date.modifydate | 20230331134421 | - |