Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 최윤희 | * |
dc.contributor.author | 박현주 | * |
dc.date.accessioned | 2016-10-14T01:10:51Z | - |
dc.date.available | 2016-10-14T01:10:51Z | - |
dc.date.issued | 2016 | * |
dc.identifier.issn | 0513-5796 | * |
dc.identifier.other | OAK-19387 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/232389 | - |
dc.description.abstract | Purpose: The aim of this study was to investigate whether the peroxisomal proliferator-activated receptor gamma (PPARγ) ligand troglitazone in combination with photodynamic therapy (PDT) enhances the apoptotic response of DLD-1 colon cancer cells. Materials and Methods: The effects of troglitazone, PDT, and troglitazone in combination with PDT on cell viability and apoptosis were assessed in DLD-1 cells. Cell viability and proliferation were evaluated using the tetrazolium-based MTT assay, and apoptosis was evaluated via cell staining with propidium iodide (PI) and annexin V-FITC. The levels of pro-caspase-3 were measured via Western blot analyses. Results: Treatment of troglitazone and PDT induced the growth retardation and cell death of DLD-1 cells in a dose-dependent manner, respectively. The combination treatment significantly suppressed cell growth and increased the apoptotic response of DLD-1 and resulted in apoptosis rather than necrosis, as shown by PI/annexin V staining and degradation of procaspase-3. Conclusion: These results document the anti-proliferative and apoptotic activities of PDT in combination with the PPARγ ligand troglitazone and provide a strong rationale for testing the therapeutic potential of combination treatment in colon cancer. © Yonsei University College of Medicine 2016. | * |
dc.language | English | * |
dc.publisher | Yonsei University College of Medicine | * |
dc.subject | Apoptosis | * |
dc.subject | PDT | * |
dc.subject | Troglitazone | * |
dc.title | Troglitazone enhances the apoptotic response of DLD-1 colon cancer cells to photodynamic therapy | * |
dc.type | Article | * |
dc.relation.issue | 6 | * |
dc.relation.volume | 57 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.index | KCI | * |
dc.relation.startpage | 1494 | * |
dc.relation.lastpage | 1499 | * |
dc.relation.journaltitle | Yonsei Medical Journal | * |
dc.identifier.doi | 10.3349/ymj.2016.57.6.1494 | * |
dc.identifier.wosid | WOS:000388219600027 | * |
dc.identifier.scopusid | 2-s2.0-84986904934 | * |
dc.author.google | Park H. | * |
dc.author.google | Ko S.-H. | * |
dc.author.google | Lee J.M. | * |
dc.author.google | Park J.H. | * |
dc.author.google | Choi Y.-H. | * |
dc.contributor.scopusid | 최윤희(7404776849) | * |
dc.contributor.scopusid | 박현주(55821533400) | * |
dc.date.modifydate | 20240123124738 | * |