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The relationship between magnesium and endothelial function in end-stage renal disease patients on hemodialysis

Title
The relationship between magnesium and endothelial function in end-stage renal disease patients on hemodialysis
Authors
Lee S.Ryu J.-H.Kim S.-J.Ryu D.-R.Kang D.-H.Choi K.B.
Ewha Authors
강덕희최규복김승정류동열
SCOPUS Author ID
강덕희scopus; 최규복scopus; 김승정scopus; 류동열scopus
Issue Date
2016
Journal Title
Yonsei Medical Journal
ISSN
0513-5796JCR Link
Citation
vol. 57, no. 6, pp. 1446 - 1453
Keywords
EndotheliumHemodialysisMagnesiumMicrocirculation
Publisher
Yonsei University College of Medicine
Indexed
SCI; SCIE; SCOPUS; KCI WOS scopus
Abstract
Purpose: Chronic kidney disease (CKD) patients tend to have higher serum magnesium values than healthy population due to their positive balance of magnesium in kidney. Recent studies found that magnesium level is positively correlated with endothelial function. Therefore, this study was conducted to define the relationship between magnesium level and endothelial dysfunction in end stage renal disease (ESRD) patients on hemodialysis (HD). Materials and Methods: A total of 27 patients were included in this cross-sectional study. Iontophoresis with laser-Doppler flowmetry, flow mediated dilation (FMD), and carotid intima-media thickness were measured. Patients’ average serum magnesium levels were measured over previous three months, including the examination month. Pearson’s correlation coefficient analysis and multivariate regression model were used to define the association between magnesium and endothelial function. Results: In the univariate analysis, higher magnesium levels were associated with better endothelium-dependent vasodilation (EDV) of the FMD in ESRD patients on HD (r=0.516, p=0.007). When the participants were divided into two groups according to the median magnesium level (3.47 mg/dL), there was a significant difference in EDV of FMD (less than 3.47 mg/dL, 2.8±1.7%; more than 3.47 mg/dL, 5.1±2.0%, p=0.004). In multivariate analysis, magnesium and albumin were identified as independent factors for FMD (β=1.794, p=0.030 for serum magnesium; β=3.642, p=0.012 for albumin). Conclusion: This study demonstrated that higher serum magnesium level may be associated with better endothelial function in ESRD patients on HD. In the future, a large, prospective study is needed to elucidate optimal range of serum magnesium levels in ESRD on HD patients. © Yonsei University College of Medicine 2016.
DOI
10.3349/ymj.2016.57.6.1446
Appears in Collections:
의과대학 > 의학과 > Journal papers
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