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Triglycerides to high-density lipoprotein cholesterol ratio can predict impaired glucose tolerance in young women with polycystic ovary syndrome

Title
Triglycerides to high-density lipoprotein cholesterol ratio can predict impaired glucose tolerance in young women with polycystic ovary syndrome
Authors
Song D.K.Lee H.Sung Y.-A.Oh J.-Y.
Ewha Authors
성연아오지영이혜진
SCOPUS Author ID
성연아scopus; 오지영scopus; 이혜진scopus
Issue Date
2016
Journal Title
Yonsei Medical Journal
ISSN
0513-5796JCR Link
Citation
vol. 57, no. 6, pp. 1404 - 1411
Keywords
CholesterolGlucose intoleranceHDLInsulin resistancePolycystic ovary syndromeTriglycerides
Publisher
Yonsei University College of Medicine
Indexed
SCI; SCIE; SCOPUS; KCI WOS scopus
Abstract
Purpose: The triglycerides to high-density lipoprotein cholesterol (TG/HDL-C) ratio could be related to insulin resistance (IR). We previously reported that Korean women with polycystic ovary syndrome (PCOS) had a high prevalence of impaired glucose tolerance (IGT). We aimed to determine the cutoff value of the TG/HDL-C ratio for predicting IR and to examine whether the TG/ HDL-C ratio is useful for identifying individuals at risk of IGT in young Korean women with PCOS. Materials and Methods: We recruited 450 women with PCOS (24±5 yrs) and performed a 75-g oral glucose tolerance test (OGTT). IR was assessed by a homeostasis model assessment index over that of the 95th percentile of regular-cycling women who served as the controls (n=450, 24±4 yrs). Results: The cutoff value of the TG/HDL-C ratio for predicting IR was 2.5 in women with PCOS. Among the women with PCOS who had normal fasting glucose (NFG), the prevalence of IGT was significantly higher in the women with PCOS who had a high TG/HDL-C ratio compared with those with a low TG/HDL-C ratio (15.6% vs. 5.6%, p<0.05). Conclusion: The cutoff value of the TG/HDL-C ratio for predicting IR was 2.5 in young Korean women with PCOS, and women with NFG and a high TG/HDL-C ratio had a higher prevalence of IGT. Therefore, Korean women with PCOS with a TG/HDL-C ratio >2.5 are recommended to be administered an OGTT to detect IGT even if they have NFG. © Yonsei University College of Medicine 2016.
DOI
10.3349/ymj.2016.57.6.1404
Appears in Collections:
의학전문대학원 > 의학과 > Journal papers
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