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Transient global amnesia: a study with Tc-99m ECD SPECT shortly after symptom onset and after recovery

Title
Transient global amnesia: a study with Tc-99m ECD SPECT shortly after symptom onset and after recovery
Authors
Kim, Bom SahnCho, Sang SooChoi, Joon YoungKim, Young Hwan
Ewha Authors
김범산
SCOPUS Author ID
김범산scopus
Issue Date
2016
Journal Title
DIAGNOSTIC AND INTERVENTIONAL RADIOLOGY
ISSN
1305-3825JCR Link1305-3612JCR Link
Citation
vol. 22, no. 5, pp. 476 - 480
Publisher
AVES
Indexed
SCIE; SCOPUS WOS scopus
Abstract
PURPOSE Transient global amnesia (TGA) is characterized by sudden loss of memory of recent events, transient inability to retain new information, and retrograde amnesia. We investigated the changes of regional cerebral blood flow in patients with TGA shortly after symptom onset and after recovery using Tc-99m-ethyl cysteinate dimer single-photon emission computed tomography (Tc-99m ECD SPECT) and statistical parametric mapping (SPM) analysis. METHODS Six right-handed patients with TGA were studied using Tc-99m ECD SPECT shortly after symptom onset and after recovery. As a control group, six healthy individuals were also studied. Images were analyzed using SPM8 using voxel-based analysis to estimate the differences between TGA patients and controls. RESULTS There was significant hypoperfusion in the left hippocampus, left thalamus, and bilateral cerebellum. In the follow-up SPECT scan, hypoperfusion in hippocampus and thalamus were restored, while hypoperfusion was noted in the temporoparietal region. CONCLUSION Our results suggest that the underlying mechanism of TGA may be temporary ischemia in the hippocampus and thalamus. There was significant restoration of perfusion in the hippocampus and thalamus after recovery from TGA.
DOI
10.5152/dir.2016.15487
Appears in Collections:
의학전문대학원 > 의학과 > Journal papers
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