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Chronic stress and moderate physical exercise prompt widespread common activation and limited differential activation in specific brain regions

Title
Chronic stress and moderate physical exercise prompt widespread common activation and limited differential activation in specific brain regions
Authors
Kim, Tae-KyungHan, Pyung-Lim
Ewha Authors
한평림
SCOPUS Author ID
한평림scopus
Issue Date
2016
Journal Title
NEUROCHEMISTRY INTERNATIONAL
ISSN
0197-0186JCR Link1872-9754JCR Link
Citation
vol. 99, pp. 252 - 261
Keywords
ExerciseChronic stressDepressionc-FosNeural activity
Publisher
PERGAMON-ELSEVIER SCIENCE LTD
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Chronic stress in rodents produces depressive behaviors, whereas moderate physical exercise counteracts stress-induced depressive behaviors. Chronic stress and physical exercise appear to produce such opposing effects by changing the neural activity of specific brain regions. However, the detailed mechanisms through which the two different types of stimuli regulate brain function in opposite directions are not clearly understood. In the present study, we attempted to explore the neuroanatomical substrates mediating stress-induced behavioral changes and anti-depressant effects of exercise by examining stimulus-dependent c-Fos induction in the brains of mice that were exposed to repeated stress or exercise in a scheduled manner. Systematic and integrated analyses of c-Fos expression profiles indicated that various brain areas, including the prelimbic cortex, lateral septal area, and paraventricular nuclei of hypothalamus were commonly and strongly activated by both stress and exercise, while the lateral habenula and hippocampus were identified as being preferentially activated by stress and exercise, respectively. Exercise-dependent c-Fos expression in all regions examined in the brain occurred in both glutamatergic and GABAergic neurons. These results suggest that chronic stress and moderate exercise produce counteractive effects on mood behaviors, along with prompting widespread common activation and limited differential activation in specific brain regions. (C) 2016 Elsevier Ltd. All rights reserved.
DOI
10.1016/j.neuint.2016.08.007
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일반대학원 > 뇌·인지과학과 > Journal papers
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