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DNA Island Formation on Binary Block Copolymer Vesicles

Title
DNA Island Formation on Binary Block Copolymer Vesicles
Authors
Luo, QingjieShi, ZhengZhang, YitaoChen, Xi-JunHan, Seo-YeonBaumgart, TobiasChenoweth, David M.Park, So-Jung
Ewha Authors
박소정
SCOPUS Author ID
박소정scopus
Issue Date
2016
Journal Title
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
ISSN
0002-7863JCR Link
Citation
vol. 138, no. 32, pp. 10157 - 10162
Publisher
AMER CHEMICAL SOC
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Here, we report DNA-induced polymer segregation and DNA island formation in binary block copolymer assemblies. A DNA diblock copolymer of polymethyl acrylateblock-DNA (PMA-b-DNA) and a triblock copolymer of poly(butadiene)-block-poly(ethylene oxide)-block-DNA (PBD-b-PEO-b-DNA) were synthesized, and each was coassembled with a prototypical amphiphilic polymer of poly(butadiene)-block-poly(ethylene oxide) (PBD-b-PEO). The binary self-assembly of PMA-b-DNA and PBD-b-PEO resulted in giant polymersomes with DNA uniformly distributed in the hydrophilic PEO shell. When giant polymersomes were connected through specific DNA interactions, DNA block copolymers migrated to the junction area, forming DNA islands within polymersomes. These results indicate that DNA hybridization can induce effective lateral polymer segregation in mixed polymer assemblies. The polymer segregation and local DNA enrichment have important implications in DNA melting properties, as mixed block copolymer assemblies with low DNA block copolymer contents can still exhibit useful DNA melting properties that are characteristic of DNA nanostructures with high DNA density.
DOI
10.1021/jacs.6b04076
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자연과학대학 > 화학·나노과학전공 > Journal papers
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