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Vitamin D and risk of respiratory tract infections in children: A systematic review and meta-analysis of randomized controlled trials

Title
Vitamin D and risk of respiratory tract infections in children: A systematic review and meta-analysis of randomized controlled trials
Authors
Ahn J.G.Lee D.Kim K.-H.
Ewha Authors
김경효안종균
SCOPUS Author ID
김경효scopus; 안종균scopus
Issue Date
2016
Journal Title
Pediatric Infection and Vaccine
ISSN
2384-1079JCR Link
Citation
vol. 23, no. 2, pp. 109 - 116
Keywords
Meta-analysisRandomized controlled trialsRespiratory tract infectionsVitamin D
Publisher
Korean Society of Pediatric Infectious Diseases
Indexed
SCOPUS scopus
Abstract
Purpose: Recent observational studies have found that vitamin D deficiency is associated with respiratory tract infections. However, randomized controlled trials (RCTs) regarding the efficacy of vitamin D in childhood respiratory tract infection (RTI) have yield inconsistent results. We performed a systematic review and meta-analysis to evaluate the association between vitamin D supplementation and the risk of RTI. Methods: A comprehensive search was conducted using MEDLINE, EMBASE, and the Cochrane Central Register of Controlled Trial. Randomized controlled trials of vitamin D supplementation for prevention of RTI in children were included for the analysis. Cochrane Collaboration’s tool for assessing the risk of bias was used to assess the quality of the studies. Pooled risk ratios with 95% confidence intervals (CIs) were meta-analyzed using Review Manager 5.3. Results: A total of seven RCTs were included in the meta-analysis. According to a random-effects model, the risk ratio for vitamin D supplementation was 0.82 (95% CI: 0.69-0.98) and I2=62% for heterogeneity. On subgroup analysis, heterogeneity decreased in the subgroup with follow-up less than 1 year, participants ≥5 years of age, patients subgroup, and subgroup with dosing daily. Funnel plot showed that there might be publication bias in the field. Conclusions: The present meta-analysis supports a beneficial effect of vitamin D supplementation for the prevention of RTI in children. However, the result should be interpreted with caution due to limitations including a small number of available RCTs, heterogeneity among the studies, and potential publication bias. © 2016, Korean Society of Pediatric Infectious Diseases. All rights reserved.
DOI
10.14776/piv.2016.23.2.109
Appears in Collections:
의과대학 > 의학과 > Journal papers
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