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Delay of Treatment Initiation Does Not Adversely Affect Survival Outcome in Breast Cancer

Title
Delay of Treatment Initiation Does Not Adversely Affect Survival Outcome in Breast Cancer
Authors
Yoo, Tae-KyungHan, WonshikMoon, Hyeong-GonKim, JisunLee, Jun WooKim, Min KyoonLee, EunshinKim, JongjinNoh, Dong-Young
Ewha Authors
이준우
SCOPUS Author ID
이준우scopus
Issue Date
2016
Journal Title
CANCER RESEARCH AND TREATMENT
ISSN
1598-2998JCR Link2005-9256JCR Link
Citation
vol. 48, no. 3, pp. 962 - 969
Keywords
Breast neoplasmsTime-to-treatmentSurvival rate
Publisher
KOREAN CANCER ASSOCIATION
Indexed
SCIE; SCOPUS; KCI WOS scopus
Abstract
Purpose Previous studies examining the relationship between time to treatment and survival outcome in breast cancer have shown inconsistent results. The aim of this study was to analyze the overall impact of delay of treatment initiation on patient survival and to determine whether certain subgroups require more prompt initiation of treatment. Materials and Methods This study is a retrospective analysis of stage I-III patients who were treated in a single tertiary institution between 2005 and 2008. Kaplan-Meier survival analysis and Cox proportional hazards regression model were used to evaluate the impact of interval between diagnosis and treatment initiation in breast cancer and various subgroups. Results A total of 1,702 patients were included. Factors associated with longer delay of treatment initiation were diagnosis at another hospital, medical comorbidities, and procedures performed before admission for surgery. An interval between diagnosis and treatment initiation as a continuous variable or with a cutoff value of 15, 30, 45, and 60 days had no impact on disease-free survival (DFS). Subgroup analyses for hormone-responsiveness, triple-negative breast cancer, young age, clinical stage, and type of initial treatment showed no significant association between longer delay of treatment initiation and DFS. Conclusion Our results show that an interval between diagnosis and treatment initiation of 60 days or shorter does not appear to adversely affect DFS in breast cancer.
DOI
10.4143/crt.2015.173
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의료원 > 의료원 > Journal papers
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