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Coordination of multiple dual oxidase-regulatory pathways in responses to commensal and infectious microbes in drosophila gut

Title
Coordination of multiple dual oxidase-regulatory pathways in responses to commensal and infectious microbes in drosophila gut
Authors
Ha E.-M.Lee K.-A.Seo Y.Y.Kim S.-H.Lim J.-H.Oh B.-H.Kim J.Lee W.-J.
Ewha Authors
이원재김재상
SCOPUS Author ID
김재상scopus
Issue Date
2009
Journal Title
Nature Immunology
ISSN
1529-2908JCR Link
Citation
vol. 10, no. 9, pp. 949 - 957
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
All metazoan guts are in permanent contact with the microbial realm. However, understanding of the exact mechanisms by which the strength of gut immune responses is regulated to achieve gut-microbe mutualism is far from complete. Here we identify a signaling network composed of complex positive and negative mechanisms that controlled the expression and activity of dual oxidase (DUOX), which 'fine tuned' the production of microbicidal reactive oxygen species depending on whether the gut encountered infectious or commensal microbes. Genetic analyses demonstrated that negative and positive regulation of DUOX was required for normal host survival in response to colonization with commensal and infectious microbes, respectively. Thus, the coordinated regulation of DUOX enables the host to achieve gut-microbe homeostasis by efficiently combating infection while tolerating commensal microbes.
DOI
10.1038/ni.1765
Appears in Collections:
일반대학원 > 바이오융합과학과 > Journal papers
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