Label-free electrochemical detection of adenosine based on electron transfer from guanine bases in an adenosine-sensitive aptamer

Abstract

The selective recognition of adenosine with an adenosine-sensitive oligonucleotide is studied via the electrochemical oxidation of guanine bases of the aptamer in solution, leading to a label-free voltammetric aptasensor based on the difference in the oxidative electron transfer rate. © The Royal Society of Chemistry 2009.