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Extract of Prunus persica flesh (PPFE) improves chemotherapeutic efficacy and protects against nephrotoxicity in cisplatin-treated mice

Title
Extract of Prunus persica flesh (PPFE) improves chemotherapeutic efficacy and protects against nephrotoxicity in cisplatin-treated mice
Authors
Chang K.L.Park K.-K.Hwang J.-K.Sang K.L.Chung W.-Y.
Ewha Authors
이상국
Issue Date
2009
Journal Title
Phytotherapy Research
ISSN
0951-418XJCR Link
Citation
vol. 23, no. 7, pp. 999 - 1005
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Cisplatin (cis-diamminedichloroplatinum II) is one of the most effective chemotherapeutic agents used in the treatment of a variety of human solid tumors. However, its clinical use is rather limited as a result of severe nephrotoxicity. The principal objective of this study was to evaluate the protective effect of Prunus persica flesh extract (PPFE) against cisplatin-induced nephrotoxicity in animal models, and whether its use influences the therapeutic efficacy of cisplatin. The administration of PPFE alone significantly inhibited the growth of CT-26 colon carcinoma xenografted onto mice without adverse effects. The combination of PPFE and cisplatin enhanced the inhibitory effect of cisplatin against tumor growth. In a xenograft model involving the repeated administration of low-dose cisplatin for 15 days, and in an acute toxicity model involving a single administration of high-dose cisplatin over a 16 h period, the administration of PPFE in combination with and prior to the cisplatin injection reversed the cisplatin-induced reduction in the kidney weight. PPFE blocked the increases in the serum blood urea nitrogen and creatinine levels associated with the kidney damage. Moreover, the administration of PPFE induced a significant reduction in cisplatin-induced oxidative stress. These results indicate that PPFE may promote the therapeutic efficacy of cisplatin therapy, while attenuating its inherent nephrotoxicity. Copyright © 2009 John Wiley & Sons, Ltd.
DOI
10.1002/ptr.2740
Appears in Collections:
약학대학 > 약학과 > Journal papers
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