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dc.contributor.author한평림-
dc.date.accessioned2016-08-29T11:08:43Z-
dc.date.available2016-08-29T11:08:43Z-
dc.date.issued2009-
dc.identifier.issn0360-4012-
dc.identifier.otherOAK-5768-
dc.identifier.urihttp://dspace.ewha.ac.kr/handle/2015.oak/232000-
dc.description.abstractThe present study was undertaken to investigate whether chronic endurance exercise affects tau phosphorylation levels in the brain with Alzheimer's disease (AD)-like pathology. To address this, the transgenic (Tg) mouse model of tauopathies, Tg-NSE/htau23, which expresses human tau23 in the brain, was chosen. Animals were subjected to chronic exercise for 3 months from 16 months of age. The exercised Tg mouse groups were treadmill run at speeds of 12 m/min (intermediate exercise group) or 19 m/min (high exercise group) for 1 hr/day, 5 days/week, during the 3-month period. Chronic endurance exercise in Tg mice increased the expression of Cu/Zn-superoxide dismutase (SOD) and catalase, and also their enzymatic activities in the brain. In parallel, chronic exercise in Tg mice up-regulated the expression of phospho-PKCα, phospho-AKT, and phospho-PI3K, and down-regulated the expressions of phospho-PKA, phosphor-p38, phospho-JNK, and phospho-ERK. Moreover, chronic exercise up-regulated both cytosolic and nuclear levels of b-catenin, and the expression of T-cell factor-4 (Tcf-4) and cyclin D1 in the brain. As a consequence of such changes, the levels of phospho-tau in the brain of Tg mice were markedly decreased after exercise. Immunohistochemical analysis showed an exercised-induced decrease of the phosphotau levels in the CA3 subregion of the hippocampus. These results suggest that chronic endurance exercise may provide a therapeutic potential to alleviate the tau pathology. © 2009 Wiley-Liss, Inc.-
dc.languageEnglish-
dc.titleRepression of tau hyperphosphorylation by chronic endurance exercise in aged transgenic mouse model of tauopathies-
dc.typeArticle-
dc.relation.issue11-
dc.relation.volume87-
dc.relation.indexSCIE-
dc.relation.indexSCOPUS-
dc.relation.startpage2561-
dc.relation.lastpage2570-
dc.relation.journaltitleJournal of Neuroscience Research-
dc.identifier.doi10.1002/jnr.22075-
dc.identifier.wosidWOS:000268118100015-
dc.identifier.scopusid2-s2.0-70349256254-
dc.author.googleLeem Y.-H.-
dc.author.googleLim H.-J.-
dc.author.googleShim S.-B.-
dc.author.googleCho J.-Y.-
dc.author.googleKim B.-S.-
dc.author.googleHan P.-L.-
dc.contributor.scopusid한평림(7201947605)-
dc.date.modifydate20170601143155-
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