Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 한평림 | - |
dc.date.accessioned | 2016-08-29T11:08:43Z | - |
dc.date.available | 2016-08-29T11:08:43Z | - |
dc.date.issued | 2009 | - |
dc.identifier.issn | 0360-4012 | - |
dc.identifier.other | OAK-5768 | - |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/232000 | - |
dc.description.abstract | The present study was undertaken to investigate whether chronic endurance exercise affects tau phosphorylation levels in the brain with Alzheimer's disease (AD)-like pathology. To address this, the transgenic (Tg) mouse model of tauopathies, Tg-NSE/htau23, which expresses human tau23 in the brain, was chosen. Animals were subjected to chronic exercise for 3 months from 16 months of age. The exercised Tg mouse groups were treadmill run at speeds of 12 m/min (intermediate exercise group) or 19 m/min (high exercise group) for 1 hr/day, 5 days/week, during the 3-month period. Chronic endurance exercise in Tg mice increased the expression of Cu/Zn-superoxide dismutase (SOD) and catalase, and also their enzymatic activities in the brain. In parallel, chronic exercise in Tg mice up-regulated the expression of phospho-PKCα, phospho-AKT, and phospho-PI3K, and down-regulated the expressions of phospho-PKA, phosphor-p38, phospho-JNK, and phospho-ERK. Moreover, chronic exercise up-regulated both cytosolic and nuclear levels of b-catenin, and the expression of T-cell factor-4 (Tcf-4) and cyclin D1 in the brain. As a consequence of such changes, the levels of phospho-tau in the brain of Tg mice were markedly decreased after exercise. Immunohistochemical analysis showed an exercised-induced decrease of the phosphotau levels in the CA3 subregion of the hippocampus. These results suggest that chronic endurance exercise may provide a therapeutic potential to alleviate the tau pathology. © 2009 Wiley-Liss, Inc. | - |
dc.language | English | - |
dc.title | Repression of tau hyperphosphorylation by chronic endurance exercise in aged transgenic mouse model of tauopathies | - |
dc.type | Article | - |
dc.relation.issue | 11 | - |
dc.relation.volume | 87 | - |
dc.relation.index | SCI | - |
dc.relation.index | SCIE | - |
dc.relation.index | SCOPUS | - |
dc.relation.startpage | 2561 | - |
dc.relation.lastpage | 2570 | - |
dc.relation.journaltitle | Journal of Neuroscience Research | - |
dc.identifier.doi | 10.1002/jnr.22075 | - |
dc.identifier.wosid | WOS:000268118100015 | - |
dc.identifier.scopusid | 2-s2.0-70349256254 | - |
dc.author.google | Leem Y.-H. | - |
dc.author.google | Lim H.-J. | - |
dc.author.google | Shim S.-B. | - |
dc.author.google | Cho J.-Y. | - |
dc.author.google | Kim B.-S. | - |
dc.author.google | Han P.-L. | - |
dc.contributor.scopusid | 한평림(7201947605) | - |
dc.date.modifydate | 20230901081001 | - |