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Urinary GADD45γ expression is associated with progression of IgA nephropathy

Title
Urinary GADD45γ expression is associated with progression of IgA nephropathy
Authors
Yu S.Cho J.Park I.Kim S.J.Kim H.Shin G.-T.
Ewha Authors
김승정
SCOPUS Author ID
김승정scopus
Issue Date
2009
Journal Title
American Journal of Nephrology
ISSN
0250-8095JCR Link
Citation
vol. 30, no. 2, pp. 135 - 139
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Background: Growth arrest and DNA damage-45γ (GADD-45γ) is induced in response to environmental stresses and functions in the regulation of cell cycles. Previous findings by our group suggested that GADD45γ contributed to renal tubular cell damage through induction of inflammatory and fibrogenic molecules. We examined the effects of urinary GADD45γ expression on the decline in renal function with IgA nephropathy in the present study. Methods: Patients (n = 62) were followed for a total of 710.3 ± 287.5 days. The rate of renal function decline was assessed by the slopes of inverse serum creatinine and estimated glomerular filtration rate (GFR) plotted against time. Renal survival was calculated by Kaplan-Meier analysis and the primary endpoint was an increase in serum creatinine levels by 50% or more. Results: Kidney function declined more rapidly in the GADD45γ-positive group compared to the GADD45γ-negative group. Kidney survival estimates at the end of the study period were 82.9% in the GADD45γ-positive group and 100% in the negative group (p = 0.03). This difference remained significant in the group with GFR values <90 ml/min/1.73 m 2 when adjusted to stratification factors. Conclusion: The results suggest that urinary GADD45γ expression is associated with progression of renal disease. Copyright © 2009 S. Karger AG.
DOI
10.1159/000209317
Appears in Collections:
의학전문대학원 > 의학과 > Journal papers
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