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The breast and ovarian cancer risks in Korea due to inherited mutations in BRCA1 and BRCA2: A preliminary report

Title
The breast and ovarian cancer risks in Korea due to inherited mutations in BRCA1 and BRCA2: A preliminary report
Authors
Sang A.H.Park S.K.Ahn S.-H.Byung H.S.Min H.L.Doo H.C.Noh D.-Y.Wonshik H.Eun S.L.Seo K.H.Lee S.K.Yongsik J.Ku S.K.Young J.S.Moon B.-I.Nam S.-J.Noh W.-C.Jeong E.L.Kim S.-W.
Ewha Authors
문병인
SCOPUS Author ID
문병인scopus
Issue Date
2009
Journal Title
Journal of Breast Cancer
ISSN
1738-6756JCR Link
Citation
vol. 12, no. 2, pp. 92 - 99
Indexed
SCIE; SCOPUS; KCI WOS scopus
Abstract
Purpose: To estimate the cumulative risk till each age (penetrance) of breast and ovarian cancers among female family members with BRCA1 and BRCA2 mutation. Methods: Among the 61 BRCA1 mutation carriers in the 42 families and 47 BRCA2 mutation carriers in 31 families identified at 5 academic breast clinics, the probands were excluded to estimate the cumulative risk till each age of breast cancer in the Korean BRCA1 and BRCA2 carriers. Using Kaplan-Meier analyses, cumulative cancer risk estimates were determined. Results: By the age 70, the female breast cancer risk for the BRCA1 and BRCA2 mutation carriers was 72.1% (95% confidence interval [CI]=59.5% to 84.8%) and 66.3% (95% CI=41.2% to 91.5%), respectively, and the ovarian cancer risk was 24.6% (95% CI=0% to 50.3%) and 11.1% (95% CI=0% to 31.6%), respectively. The contralateral breast cancer risk at 5 years after primary breast cancer was estimated as 16.2% (95% CI=9.3% to 23.1%) for the 52 breast cancer patients with the BRCA1 mutation and 17.3% (95% CI=9.7% to 24.0%) for the 35 breast cancer patients with the BRCA2 mutation. Conclusion: The penetrance of BRCA mutations in Korea is largely consistent with the previous studies on Western populations. However, the small number of the cases, the high proportions of probands in the study subjects, the short term follow-up, and large confidence intervals are the limitations of the current study. The Korean Hereditary Breast Cancer Study (KOHBRA Study) may definitely answer this question.
DOI
10.4048/jbc.2009.12.2.92
Appears in Collections:
의학전문대학원 > 의학과 > Journal papers
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