Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 문병인 | * |
dc.contributor.author | 이령아 | * |
dc.contributor.author | 최국진 | * |
dc.date.accessioned | 2016-08-29T11:08:06Z | - |
dc.date.available | 2016-08-29T11:08:06Z | - |
dc.date.issued | 2009 | * |
dc.identifier.issn | 1738-6756 | * |
dc.identifier.other | OAK-5747 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/231985 | - |
dc.description.abstract | Purpose: It has been demonstrated ellagic acid can inhibit tumor growth. However, the mechanism that elicits the anti-proliferative effect of ellagic acid is poorly understood. Our objective in this study was to evaluate the biological activity of ellagic acid by comparing the anti-proliferative effect and the apoptotic pathway of ellagic acid between the 2 human breast cancer cell lines. Methods: The MCF-7 and MDA-MB-231 human breast cancer cell lines were used as cell models. The anti-proliferstive effect was evaluated by using a MTT assay. The cell cycle was analyzed by flow cytometry. Western blotting was performed to show the expressions of bcl-xL, cytochrome c, surviving, c-fos and pS2. Results: The ellagic acid in the MDA-MB-231 cells showed significant anti-proliferative effects with dose dependent pattern. The anti-proliferative effects in MCF-7 cells were observed in only at a high concentration. Ellagic acid had no effect on the cell cycle in both breast cancer cells. In MDA-MB-231, the expression of bcl-xL was decreased with the decreasing concentration of ellagic acid. The expression of cytochrome c in the cytosol was increased with the decreased expression of bcl-xL. Ellagic acid also decreased the expression of survivin. In the MCF-7 cells, the expressions of bcl-xL and cytochrome c showed no change after treatment with ellagic acid even at a high dose. Ellagic acid was able to induce an upregulation of c-fos and pS2 protein in MCF-7. Conclusion: Ellagic acid has an anti-proliferative effect in the MDA-MB-231 cells. This effect of ellagic acid is through the intrinsic pathway in MDA-MB-231 cells. However, the expression of bcl-xL showed no change in the MCF-7 cells. Ellagic acid has a different anti-proliferative effect between the two human breast cancer cell lines. | * |
dc.language | English | * |
dc.title | Ellagic acid shows different anti-proliferative effects between the MDA-MB-231 and MCF-7 human breast cancer cell lines | * |
dc.type | Article | * |
dc.relation.issue | 2 | * |
dc.relation.volume | 12 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.index | KCI | * |
dc.relation.startpage | 85 | * |
dc.relation.lastpage | 91 | * |
dc.relation.journaltitle | Journal of Breast Cancer | * |
dc.identifier.doi | 10.4048/jbc.2009.12.2.85 | * |
dc.identifier.wosid | WOS:000267771100005 | * |
dc.identifier.scopusid | 2-s2.0-71049152786 | * |
dc.author.google | Kim H.-A. | * |
dc.author.google | Lee R.-A. | * |
dc.author.google | Moon B.-I. | * |
dc.author.google | Choe K.-J. | * |
dc.contributor.scopusid | 문병인(7101878644;56119062300) | * |
dc.contributor.scopusid | 이령아(12753883700) | * |
dc.date.modifydate | 20240118165121 | * |