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Effect of compound K, a metabolite of ginseng saponin, combined with γ-ray radiation in human lung cancer cells in vitro and in vivo

Title
Effect of compound K, a metabolite of ginseng saponin, combined with γ-ray radiation in human lung cancer cells in vitro and in vivo
Authors
Chae S.Kang K.A.Chang W.Y.Kim M.J.Lee S.J.Lee Y.S.Kim H.S.Kim D.H.Hyun J.W.
Ewha Authors
김희선이윤실
SCOPUS Author ID
김희선scopus; 이윤실scopus
Issue Date
2009
Journal Title
Journal of Agricultural and Food Chemistry
ISSN
0021-8561JCR Link
Citation
vol. 57, no. 13, pp. 5777 - 5782
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Pretreatment of NCI-H460 human lung cancer cells with compound K produced by intestinal bacteria enhances γ-ray radiation-induced cell death. Increases in apoptosis induced by combined treatment are made apparent in the observation of nuclear fragmentation, loss of mitochondrial membrane potential (Δ ψ), and activation of caspase 3. Apoptosis induced by compound K and γ-ray radiation is associated with reactive oxygen species (ROS) generation. Furthermore, compound K, in combination with γ-ray radiation, has an enhanced effect in the regression of NCI-H460 tumor xenografts of nude mice. These results suggest that compound K has possible application for cancer therapy when used in combination with γ-ray radiation. © 2009 American Chemical Society.
DOI
10.1021/jf900331g
Appears in Collections:
의학전문대학원 > 의학과 > Journal papers
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