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Mesenchymal stem cells showed the highest potential for the regeneration of injured liver tissue compared with other subpopulations of the bone marrow

Title
Mesenchymal stem cells showed the highest potential for the regeneration of injured liver tissue compared with other subpopulations of the bone marrow
Authors
Cho K.-A.Ju S.-Y.Cho S.J.Jung Y.-J.Woo S.-Y.Seoh J.-Y.Han H.-S.Ryu K.-H.
Ewha Authors
서주영유경하우소연조수진
SCOPUS Author ID
서주영scopus; 유경하scopus; 우소연scopus; 조수진scopus
Issue Date
2009
Journal Title
Cell Biology International
ISSN
1065-6995JCR Link
Citation
vol. 33, no. 7, pp. 772 - 777
Indexed
SCIE; SCOPUS WOS scopus
Abstract
We have previously reported that bone marrow cells (BMCs) participate in the regeneration after liver injury. However, it is not established that this is the result of differentiation of hematopoietic stem cells (HSCs), mesenchymal stem cells (MSCs) or the combination of both. We investigated the contribution of each cell fraction to the regenerative process. First, we confirmed that transplanted stem cells migrate directly to injured liver tissue without dispersing to other organs. Next, we divided green fluorescent protein (GFP)-expressing BMCs into three populations as mononuclear cells, MSCs and HSCs. We then compared the engraftment capacity after transplantation of each fraction of cells into liver-injured mice. Of these, the MSCs transplanted group showed the highest GFP fluorescence intensities in liver tissue by flow cytometry analysis and confocal microscopic observation. Furthermore, MSCs showed differentiation potential into hepatocytes when co-cultured with injured liver cells, which suggests that MSCs showed highest potential for the regeneration of injured liver tissue compared with those of the other two cell refractions. © 2009 International Federation for Cell Biology.
DOI
10.1016/j.cellbi.2009.04.023
Appears in Collections:
의학전문대학원 > 의학과 > Journal papers
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