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ERK activation induced by selenium treatment significantly downregulates β/γ-secretase activity and Tau phosphorylation in the transgenic rat overexpressing human selenoprotein M

Title
ERK activation induced by selenium treatment significantly downregulates β/γ-secretase activity and Tau phosphorylation in the transgenic rat overexpressing human selenoprotein M
Authors
Yim S.Y.Chae K.R.Shim S.B.Hong J.T.Park J.Y.Lee C.Y.Son H.J.Sheen Y.Y.Hwang D.Y.
Ewha Authors
신윤용
SCOPUS Author ID
신윤용scopus
Issue Date
2009
Journal Title
International Journal of Molecular Medicine
ISSN
1107-3756JCR Link
Citation
vol. 24, no. 1, pp. 91 - 96
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Selenium reportedly contribute to the modulation process of protein phosphorylation to regulate various cellular functions including growth, differentiation, proliferation and development. The aim of this study was to investigate whether selenium and Selenoprotein M (SelM) affects the mechanism of Alzheimer's disease. To achieve this, we determined the change of the MAPK pathway, secretase activity, and Tau phosphorylation in the transgenic rat overexpressing human selenoprotein M. Based on these results, we concluded that, i) CMV/GFP-hSelM Tg rats showed a high activity level of antioxidant enzyme in the brain tissues, ii) in response to selenium treatment, the ERK signaling pathway was significantly increased in Tg rats, but did not change in wild-type rats, iii) the activation of the ERK pathway by selenium treatment and SelM overexpression induced the inhibition of the α/ γ-secretase activity related to the protection of Aβ-42 production, iv) the activation of the ERK pathway by selenium treatment and SelM overexpression inhibited the phosphorylation in several sites of Tau protein. Therefore, these results provide strong evidence that selenium treatment and SelM activate the ERK pathway to attenuate α/γ-secretase-mediated proteolysis and Tau phosphorylation to protect brain function.
DOI
10.3892/ijmm_00000211
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약학대학 > 약학과 > Journal papers
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