View : 41 Download: 0

Inorganic drug-delivery nanovehicle conjugated with cancer-cell-specific ligand

Title
Inorganic drug-delivery nanovehicle conjugated with cancer-cell-specific ligand
Authors
Oh J.-M.Choi S.-J.Lee G.-E.Han S.-H.Choy J.-H.
Ewha Authors
최진호
SCOPUS Author ID
최진호scopus
Issue Date
2009
Journal Title
Advanced Functional Materials
ISSN
1616-301XJCR Link
Citation
vol. 19, no. 10, pp. 1617 - 1624
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
The surface of layered double hydroxide nanoparticles, a potential drugdelivery nanovehicle, is modified with the cancer-cell-specific ligand, folic acid. The surface modification is successfully accomplished through step-bystep coupling reactions with aminopropyltriethoxysilane and 1-ethyl-3-(3- dimethyl aminopropyl)-carbodiimide. In order to evaluate the cancer-cell targeting effect of folic-acid-grafted layered double hydroxide utilizing fluorescence-related assay, both layered double hydroxide with and without folic acid moiety are labeled with fluorescein 50-isothiocyanate. The uptake of layered double hydroxide and folic acid conjugated into KB and A549 cells is visualized using fluorescence microscopy and measured by flow cytometry. Both chemical and biological assay results demonstrate that the folic acid molecules are indeed conjugated to the surface of layered double hydroxide and thus the selectivity of nanovehicles to cancer cells overexpressing folate receptors increases. In this study, it is suggested that layered double hydroxide nanoparticles can be used as drug-delivery carriers with a targeting function due to the chemical conjugation with specific ligand.
DOI
10.1002/adfm.200801127
Appears in Collections:
자연과학대학 > 화학·나노과학전공 > Journal papers
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE