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dc.contributor.author장준-
dc.date.accessioned2017-08-28T20:05:42Z-
dc.date.available2017-08-28T20:05:42Z-
dc.date.issued2009-
dc.identifier.issn1521-6616-
dc.identifier.otherOAK-5638-
dc.identifier.urihttp://dspace.ewha.ac.kr/handle/2015.oak/231928-
dc.description.abstractT-bet is a Th1-specific transcription factor that is directly involved in three important pathways for Th1 cell differentiation, namely TCR signaling, and the IFN-γ-STAT1 and IL-12-STAT4 pathways. A recent study also showed that T-bet plays a vital role in innate immunity. However, the molecular mechanism responsible for transcriptional activation of T-bet during T cell development is not yet known. Here, we characterize the essential human T-bet promoter elements and show that binding of EGR1 to this promoter induces T-bet transcription. Notably, overexpression of EGR1 transactivates and, synergistically in concert with TCR signaling, induces T-bet expression in activated T cells. In contrast, depletion of EGR1 significantly decreases T-bet induction. Finally, we report a positive correlation between EGR1 and T-bet expression during T helper cell differentiation. Collectively, these findings provide molecular insight into T-bet transcription and suggest that EGR1 is an upstream regulator of T-bet induction. © 2009 Elsevier Inc. All rights reserved.-
dc.languageEnglish-
dc.titleT-bet expression is regulated by EGR1-mediated signaling in activated T cells-
dc.typeArticle-
dc.relation.issue3-
dc.relation.volume131-
dc.relation.indexSCI-
dc.relation.indexSCIE-
dc.relation.indexSCOPUS-
dc.relation.startpage385-
dc.relation.lastpage394-
dc.relation.journaltitleClinical Immunology-
dc.identifier.doi10.1016/j.clim.2009.02.009-
dc.identifier.wosidWOS:000266342100003-
dc.identifier.scopusid2-s2.0-67349179539-
dc.author.googleShin H.-J.-
dc.author.googleLee J.-B.-
dc.author.googlePark S.-H.-
dc.author.googleChang J.-
dc.author.googleLee C.-W.-
dc.contributor.scopusid장준(8735999100)-
dc.date.modifydate20170601133930-
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약학대학 > 약학과 > Journal papers
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