Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 장준 | * |
dc.date.accessioned | 2016-08-29T11:08:46Z | - |
dc.date.available | 2016-08-29T11:08:46Z | - |
dc.date.issued | 2009 | * |
dc.identifier.issn | 1521-6616 | * |
dc.identifier.other | OAK-5638 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/231928 | - |
dc.description.abstract | T-bet is a Th1-specific transcription factor that is directly involved in three important pathways for Th1 cell differentiation, namely TCR signaling, and the IFN-γ-STAT1 and IL-12-STAT4 pathways. A recent study also showed that T-bet plays a vital role in innate immunity. However, the molecular mechanism responsible for transcriptional activation of T-bet during T cell development is not yet known. Here, we characterize the essential human T-bet promoter elements and show that binding of EGR1 to this promoter induces T-bet transcription. Notably, overexpression of EGR1 transactivates and, synergistically in concert with TCR signaling, induces T-bet expression in activated T cells. In contrast, depletion of EGR1 significantly decreases T-bet induction. Finally, we report a positive correlation between EGR1 and T-bet expression during T helper cell differentiation. Collectively, these findings provide molecular insight into T-bet transcription and suggest that EGR1 is an upstream regulator of T-bet induction. © 2009 Elsevier Inc. All rights reserved. | * |
dc.language | English | * |
dc.title | T-bet expression is regulated by EGR1-mediated signaling in activated T cells | * |
dc.type | Article | * |
dc.relation.issue | 3 | * |
dc.relation.volume | 131 | * |
dc.relation.index | SCI | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 385 | * |
dc.relation.lastpage | 394 | * |
dc.relation.journaltitle | Clinical Immunology | * |
dc.identifier.doi | 10.1016/j.clim.2009.02.009 | * |
dc.identifier.wosid | WOS:000266342100003 | * |
dc.identifier.scopusid | 2-s2.0-67349179539 | * |
dc.author.google | Shin H.-J. | * |
dc.author.google | Lee J.-B. | * |
dc.author.google | Park S.-H. | * |
dc.author.google | Chang J. | * |
dc.author.google | Lee C.-W. | * |
dc.contributor.scopusid | 장준(8735999100) | * |
dc.date.modifydate | 20231120165756 | * |