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dc.contributor.author장준*
dc.date.accessioned2016-08-29T11:08:46Z-
dc.date.available2016-08-29T11:08:46Z-
dc.date.issued2009*
dc.identifier.issn1521-6616*
dc.identifier.otherOAK-5638*
dc.identifier.urihttps://dspace.ewha.ac.kr/handle/2015.oak/231928-
dc.description.abstractT-bet is a Th1-specific transcription factor that is directly involved in three important pathways for Th1 cell differentiation, namely TCR signaling, and the IFN-γ-STAT1 and IL-12-STAT4 pathways. A recent study also showed that T-bet plays a vital role in innate immunity. However, the molecular mechanism responsible for transcriptional activation of T-bet during T cell development is not yet known. Here, we characterize the essential human T-bet promoter elements and show that binding of EGR1 to this promoter induces T-bet transcription. Notably, overexpression of EGR1 transactivates and, synergistically in concert with TCR signaling, induces T-bet expression in activated T cells. In contrast, depletion of EGR1 significantly decreases T-bet induction. Finally, we report a positive correlation between EGR1 and T-bet expression during T helper cell differentiation. Collectively, these findings provide molecular insight into T-bet transcription and suggest that EGR1 is an upstream regulator of T-bet induction. © 2009 Elsevier Inc. All rights reserved.*
dc.languageEnglish*
dc.titleT-bet expression is regulated by EGR1-mediated signaling in activated T cells*
dc.typeArticle*
dc.relation.issue3*
dc.relation.volume131*
dc.relation.indexSCI*
dc.relation.indexSCIE*
dc.relation.indexSCOPUS*
dc.relation.startpage385*
dc.relation.lastpage394*
dc.relation.journaltitleClinical Immunology*
dc.identifier.doi10.1016/j.clim.2009.02.009*
dc.identifier.wosidWOS:000266342100003*
dc.identifier.scopusid2-s2.0-67349179539*
dc.author.googleShin H.-J.*
dc.author.googleLee J.-B.*
dc.author.googlePark S.-H.*
dc.author.googleChang J.*
dc.author.googleLee C.-W.*
dc.contributor.scopusid장준(8735999100)*
dc.date.modifydate20231120165756*
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약학대학 > 약학과 > Journal papers
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