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Anti-inflammatory mechanism of ginseng saponins in activated microglia

Title
Anti-inflammatory mechanism of ginseng saponins in activated microglia
Authors
Park J.-S.Park E.-M.Kim D.-H.Jung K.Jung J.-S.Lee E.-J.Hyun J.-W.Kang J.L.Kim H.-S.
Ewha Authors
이지희김희선박은미
SCOPUS Author ID
이지희scopus; 김희선scopus; 박은미scopus
Issue Date
2009
Journal Title
Journal of Neuroimmunology
ISSN
0165-5728JCR Link
Citation
vol. 209, no. 41276, pp. 40 - 49
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
In the present study, we investigated the effect of ginseng extract (KRG) and total saponins (GTS) on microglial activation. KRG and GTS inhibited LPS-induced expression of iNOS, MMP-9 and proinflammatory cytokines in microglial cells. Suppression of microglial activation by ginseng was also observed in the mouse brain inflamed by LPS. Furthermore, KRG and GTS significantly suppressed NF-κB and MAP kinase activities, which are upstream signaling molecules in inflammation. Among the individual ginsenosides tested, Rh2, Rh3 and compound K significantly inhibited LPS-induced iNOS and cytokine expressions. Therefore, the inhibition of microglial activation by ginseng saponins may a good potential therapeutic modality for neurodegenerative diseases. © 2009 Elsevier B.V. All rights reserved.
DOI
10.1016/j.jneuroim.2009.01.020
Appears in Collections:
의학전문대학원 > 의학과 > Journal papers
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