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Anti-inflammatory mechanism of ginseng saponins in activated microglia

Title
Anti-inflammatory mechanism of ginseng saponins in activated microglia
Authors
Park J.-S.Park E.-M.Kim D.-H.Jung K.Jung J.-S.Lee E.-J.Hyun J.-W.Kang J.L.Kim H.-S.
Ewha Authors
이지희김희선박은미
SCOPUS Author ID
이지희scopus; 김희선scopus; 박은미scopus
Issue Date
2009
Journal Title
Journal of Neuroimmunology
ISSN
0165-5728JCR Link
Citation
Journal of Neuroimmunology vol. 209, no. 41276, pp. 40 - 49
Indexed
SCI; SCIE; SCOPUS WOS scopus
Document Type
Article
Abstract
In the present study, we investigated the effect of ginseng extract (KRG) and total saponins (GTS) on microglial activation. KRG and GTS inhibited LPS-induced expression of iNOS, MMP-9 and proinflammatory cytokines in microglial cells. Suppression of microglial activation by ginseng was also observed in the mouse brain inflamed by LPS. Furthermore, KRG and GTS significantly suppressed NF-κB and MAP kinase activities, which are upstream signaling molecules in inflammation. Among the individual ginsenosides tested, Rh2, Rh3 and compound K significantly inhibited LPS-induced iNOS and cytokine expressions. Therefore, the inhibition of microglial activation by ginseng saponins may a good potential therapeutic modality for neurodegenerative diseases. © 2009 Elsevier B.V. All rights reserved.
DOI
10.1016/j.jneuroim.2009.01.020
Appears in Collections:
의과대학 > 의학과 > Journal papers
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