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dc.contributor.author김양하-
dc.date.accessioned2017-08-28T20:05:28Z-
dc.date.available2017-08-28T20:05:28Z-
dc.date.issued2009-
dc.identifier.issn0250-6807-
dc.identifier.otherOAK-5581-
dc.identifier.urihttp://dspace.ewha.ac.kr/handle/2015.oak/231914-
dc.description.abstractAims: The aim of this study was to investigate the antiobesity effect of (-)-epigallocatechin-3-gallate (EGCG) in diet-induced obese mice. Methods: Male C57BL/6J mice were fed on a high-fat diet for 8 weeks to induce obesity. Subsequently they were divided into 3 groups and were maintained on a high-fat control diet or high-fat diets supplemented with 0.2 or 0.5% EGCG (w/w) for a further 8 weeks. Changes in the expression of genes related to lipid metabolism and fatty acid oxidation were analyzed in white adipose tissue, together with biometric and blood parameters. Results: Experimental diets supplemented with EGCG resulted in reduction of body weight and mass of various adipose tissues in a dose-dependent manner. EGCG diet also considerably lowered the levels of plasma triglyceride and liver lipid. In the epididymal white adipose tissue of EGCG diet-fed mice, the mRNA levels of adipogenic genes such as peroxisome proliferator-activated receptor-γ (PPAR-γ), CCAAT enhancer-binding protein-α (C/EBP-α), regulatory element-binding protein-1c (SREBP-1c), adipocyte fatty acid-binding protein (aP2), lipoprotein lipase (LPL) and fatty acid synthase (FAS) were significantly decreased. However, the mRNA levels of carnitine palmitoyl transferase-1 (CPT-1) and uncoupling protein 2 (UCP2), as well as lipolytic genes such as hormone sensitive lipase (HSL) and adipose triglyceride lipase (ATGL), were significantly increased. Conclusion: These results suggest that green tea EGCG effectively reduces adipose tissue mass and ameliorates plasma lipid profiles in high-fat diet-induced obese mice. These effects might be at least partially mediated via regulation of the expression of multiple genes involved in adipogenesis, lipolysis, β-oxidation and thermogenesis in white adipose tissue. © 2009 S. Karger AG, Basel.-
dc.languageEnglish-
dc.titleGreen tea (-)-epigallocatechin-3-gallate reduces body weight with regulation of multiple genes expression in adipose tissue of diet-induced obese mice-
dc.typeArticle-
dc.relation.issue2-
dc.relation.volume54-
dc.relation.indexSCI-
dc.relation.indexSCIE-
dc.relation.indexSCOPUS-
dc.relation.startpage151-
dc.relation.lastpage157-
dc.relation.journaltitleAnnals of Nutrition and Metabolism-
dc.identifier.doi10.1159/000214834-
dc.identifier.wosidWOS:000265628200011-
dc.identifier.scopusid2-s2.0-65449125891-
dc.author.googleLee M.-S.-
dc.author.googleKim C.-T.-
dc.author.googleKim Y.-
dc.contributor.scopusid김양하(8524160300)-
dc.date.modifydate20170508110102-
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신산업융합대학 > 식품영양학과 > Journal papers
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