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Application of column-switching HPLC method in evaluating pharmacokinetic parameters of zaltoprofen and its salt

Title
Application of column-switching HPLC method in evaluating pharmacokinetic parameters of zaltoprofen and its salt
Authors
Yang H.K.Kim S.Y.Kim J.S.Sah H.Lee H.J.
Ewha Authors
이화정사홍기
SCOPUS Author ID
이화정scopus; 사홍기scopus
Issue Date
2009
Journal Title
Biomedical Chromatography
ISSN
0269-3879JCR Link
Citation
vol. 23, no. 5, pp. 537 - 542
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
The objective of this study was to compare the pharmacokinetic parameters of zaltoprofen and those of its sodium salt in rats. Zaltoprofen, a potent non-steroidal anti-inflammatory agent, was virtually insoluble in water, but its sodium salt had excellent water solubility. To investigate the effect of aqueous solubility differences upon their pharmacokinetic parameters, minicapsules containing the drug powders were administrated orally to rats, and blood samples were taken via the common carotid artery. A column-switching high-performance liquid chromatographic analytical procedure was developed and validated for the quantitation of zaltoprofen in rat plasma samples. Our study demonstrated that the time required to reach maximum plasma concentration (Tmax) of zaltoprofen sodium was significantly reduced and its maximum plasma concentration (Cmax) was increased 1.5-fold, relative to the values for zaltoprofen. It is anticipated that the sodium salt of zaltoprofen will allow the rapid onset of the drug's action in the treatment of inflammatory diseases. Copyright © 2008 John Wiley & Sons, Ltd.
DOI
10.1002/bmc.1151
Appears in Collections:
약학대학 > 약학과 > Journal papers
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