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Lactobacillus colonization status in infants with urinary tract infection

Title
Lactobacillus colonization status in infants with urinary tract infection
Authors
Lee J.W.Shim Y.H.Lee S.J.
Ewha Authors
이승주
SCOPUS Author ID
이승주scopusscopus
Issue Date
2009
Journal Title
Pediatric Nephrology
ISSN
0931-041XJCR Link
Citation
vol. 24, no. 1, pp. 135 - 139
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
To explore the potential protective role of urogenital lactobacilli against urinary tract infection (UTI), lactobacillus cultures were performed on stool and urine specimens and periurethral/vaginal swabs of febrile infants who were suspected of having UTI. Those infants diagnosed with UTI based on the results of the suprapubic urine cultures were allocated to the UTI group (n=60), and those who had a simple viral illness with negative urine cultures were allocated to the control group (n=31). Lactobacilli were anaerobically cultured in lactobacillus-specific DifcoTM Rogosa SL agar for 48 h at 37°C and then counted. The lactobacillus colony counts for the stool and urine specimens and periurethral swabs from the UTI group were significantly lower than those for the control group (P<0.05). The geometric means of stool, periurethra, and urine lactobacilli in the UTI group were significantly lower than those in the control group (P<0.05). The colony count of the vaginal lactobacillus demonstrated an equivocal difference between the UTI and control group. In conclusion, this is the first prospective case-control study to demonstrate reduced lactobacillus urogenital colonization in infants with UTI. Our results support the view that less urogenital lactobacillus colonization may be a risk factor for UTI in infants even though there is an unclear possibility that the UTI itself could be the cause of the lower lactobacillus colonies. © IPNA 2008.
DOI
10.1007/s00467-008-0974-z
Appears in Collections:
의과대학 > 의학과 > Journal papers
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