View : 12 Download: 0

The CCR5 (-2135C/T) polymorphism may be associated with the development of kawasaki disease in Korean children

Title
The CCR5 (-2135C/T) polymorphism may be associated with the development of kawasaki disease in Korean children
Authors
Jhang W.K.Kang M.-J.Jin H.-S.Yu J.Kim B.-J.Kim B.S.Lee J.-K.Seo E.-J.Yoo H.-W.Park I.S.Hong Y.M.Hong S.-J.
Ewha Authors
홍영미
SCOPUS Author ID
홍영미scopus
Issue Date
2009
Journal Title
Journal of Clinical Immunology
ISSN
0271-9142JCR Link
Citation
vol. 29, no. 1, pp. 22 - 28
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Background: Kawasaki disease (KD) is an acute vasculitis syndrome of unknown etiology that frequently affects small to medium size arteries. C-C chemokine receptor 5 (CCR5) is a chemokine receptor that binds C-C chemokines. This study investigated the association of the CCR5 (-2135C/T) polymorphism with KD in Korean children. Methods: The study population consisted 189 Korean children with KD and 194 Korean children with congenital heart disease (CHD). CCR5 (-2135C/T) polymorphism genotypes were determined using the single-base extension method. Results: The allele frequencies of the CCR5 (-2135C/T) polymorphism differed significantly between CHD children and KD children (-2135T/T, 16.75% vs. 30.05%, aOR 2.14, 95% CI 1.31-3.51). The tested laboratory parameters differed significantly between the KD and CHD groups. The development of coronary artery aneurysm in KD patients was not associated with the CCR5 polymorphism. Conclusions: Our findings suggest that the T allele at the CCR5 (-2135C/T) polymorphism might be associated with the development of KD in Korean children but does not appear to be associated with the development of coronary artery aneurysm. © 2008 Springer Science+Business Media, LLC.
DOI
10.1007/s10875-008-9218-z
Appears in Collections:
의학전문대학원 > 의학과 > Journal papers
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE