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Clinical Implication of Serum C-Reactive Protein in Patients With Uncomplicated Acute Pyelonephritis as Marker of Prolonged Hospitalization and Recurrence

Title
Clinical Implication of Serum C-Reactive Protein in Patients With Uncomplicated Acute Pyelonephritis as Marker of Prolonged Hospitalization and Recurrence
Authors
Yang W.J.Cho I.R.Seong D.H.Song Y.S.Lee D.H.Song K.H.Cho K.S.Sung Hong W.Kim H.S.
Ewha Authors
이동현
SCOPUS Author ID
이동현scopus
Issue Date
2009
Journal Title
Urology
ISSN
0090-4295JCR Link
Citation
vol. 73, no. 1, pp. 19 - 22
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Objectives: To analyze the clinical value of C-reactive protein (CRP) as a marker of prolonged hospitalization and a predictor of recurrence in patients after uncomplicated acute pyelonephritis (APN). Methods: A total of 202 consecutive adult patients with APN were prospectively enrolled from September 2005 to June 2007. APN was defined as the concomitant presence of 4 major and ≥2 minor clinical or laboratory signs or symptoms suggestive of APN. All patients were treated with parenteral antibiotics. The patients were discharged after normalization of body temperature, serum white blood cell counts, and urinalysis. Correlations among the recurrence of APN and various factors, including CRP, were investigated. Results: Of the 202 patients, 13 were excluded because of the presence of complicating factors or insufficient data. APN recurrence developed in 4 patients (2.1%). The CRP level at discharge correlated significantly with the recurrence of APN on univariate and multivariate analysis. Irrespective of the normalization of body temperature, serum white blood cell counts, and urinalysis, the recurrence of APN was significantly greater in the patients with CRP >4 mg/dL than in those with <4 mg/dL at discharge. Patients with a maximal CRP of >15 mg/dL during admission had a longer hospitalization and required more intravenous antibiotic therapy than did the patients with a maximal CRP of <15 mg/dL. Conclusions: As a marker of prolonged hospitalization and recurrence, CRP can complement the present clinical and laboratory parameters used as guides in the proper treatment of patients with uncomplicated APN. © 2009.
DOI
10.1016/j.urology.2008.07.061
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의학전문대학원 > 의학과 > Journal papers
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