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Effect of hypoxic treatment on bone marrow cells that are able to migrate to the injured liver

Title
Effect of hypoxic treatment on bone marrow cells that are able to migrate to the injured liver
Authors
Ju S.-Y.Cho K.-A.Cho S.J.Jung Y.-J.Woo S.-Y.Seoh J.-Y.Han H.-S.Ryu K.-H.
Ewha Authors
서주영유경하우소연조수진
SCOPUS Author ID
서주영scopus; 유경하scopus; 우소연scopus; 조수진scopus
Issue Date
2009
Journal Title
Cell Biology International
ISSN
1065-6995JCR Link
Citation
vol. 33, no. 1, pp. 31 - 35
Indexed
SCIE; SCOPUS WOS scopus
Abstract
Restricted numbers and poor regenerative properties limit the use of adult stem cells. We tested the effect of hypoxic treatment as a method by which to increase cell migration. Bone marrow cells (BMCs) were cultured under oxygen saturations of 0.1, 3, and 20% for 24 h. After hypoxic treatment, BMCs of apoptotic fraction were decreased. The expression of CXCR4 was noticeably increased in the hypoxia-treated BMCs and their migration in response to SDF-1α was enhanced compared with cells cultured under normoxic condition. Hypoxic BMCs had a higher degree of engraftment to the CCl 4-injured liver than the normoxic cells. Hypoxic treatment of BMCs may have merits in decreasing apoptosis of those cells as well as in enhancing cellular migration to SDF-1α, the chemokine which binds to BMCs expressed CXCR4 and to the injured tissue, such as CCl 4 damaged liver. © 2008 International Federation for Cell Biology.
DOI
10.1016/j.cellbi.2008.10.002
Appears in Collections:
의과대학 > 의학과 > Journal papers
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