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Harnessing the Therapeutic Potential of Capsaicin and Its Analogues in Pain and Other Diseases

Title
Harnessing the Therapeutic Potential of Capsaicin and Its Analogues in Pain and Other Diseases
Authors
Basith, ShaherinCui, MinghuaHong, SunhyeChoi, Sun
Ewha Authors
최선
SCOPUS Author ID
최선scopus
Issue Date
2016
Journal Title
MOLECULES
ISSN
1420-3049JCR Link
Citation
vol. 21, no. 8
Keywords
capsaicintherapeuticanaloguesneuropathic paindesensitization
Publisher
MDPI AG
Indexed
SCIE; SCOPUS WOS scopus
Abstract
Capsaicin is the most predominant and naturally occurring alkamide found in Capsicum fruits. Since its discovery in the 19th century, the therapeutic roles of capsaicin have been well characterized. The potential applications of capsaicin range from food flavorings to therapeutics. Indeed, capsaicin and few of its analogues have featured in clinical research covered by more than a thousand patents. Previous records suggest pleiotropic pharmacological activities of capsaicin such as an analgesic, anti-obesity, anti-pruritic, anti-inflammatory, anti-apoptotic, anti-cancer, anti-oxidant, and neuro-protective functions. Moreover, emerging data indicate its clinical significance in treating vascular-related diseases, metabolic syndrome, and gastro-protective effects. The dearth of potent drugs for management of such disorders necessitates the urge for further research into the pharmacological aspects of capsaicin. This review summarizes the historical background, source, structure and analogues of capsaicin, and capsaicin-triggered TRPV1 signaling and desensitization processes. In particular, we will focus on the therapeutic roles of capsaicin and its analogues in both normal and pathophysiological conditions.
DOI
10.3390/molecules21080966
Appears in Collections:
약학대학 > 약학과 > Journal papers
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